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Models

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Mice

hSIRPA(2)/hCD47/hPD-1/hPD-L1(2)

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Pdcd1tm1(hPDCD1)Cd274tm2(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220029

hSIRPA(2)(NM-HU-18015), hCD47(NM-HU-00050) and hPD-1(NM-HU-00015) was crossed with hPD-L1(2)(NM-HU-190039）to generate hSIRPA(2)/hCD47/hPD-1/hPD-L1(2) mice.

Mice

R26-CAG-LSL-hNRF2-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-NRF2-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18050

A SA-2xpolyA-CAG-LSL-human NRF2-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase to express human NRF2 and a reporter gene in certain cells or tissues that expressing Cre recombinase.

Mice

Foxp3-V5-AviTag-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Foxp3em1(V5-AviTag-IRES-luci-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18034

A V5-AviTag-IRES-luci-2A-tdTomato expression cassette was inserted before the stop codon TGA of mouse Foxp3 gene to establish a multi-labeled knockin model with V5, Avi, luciferase and tdTomato fluorescent protein.

Mice

hANGPTL3(4)

Strain Name：C57BL/6Smoc-Angptl3tm1(hANGPTL3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210036
Validation Data：Presence

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

h4-1BB(2)/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210357

h4-1BB(2)(NM-HU-190077), hPD-L1(NM-HU-00062) and hPD-1(NM-HU-00015) was crossed together to generate h4-1BB(2)/hPD-1/hPD-L1 mice.

Mice

hANGPTL3(3)

Strain Name：C57BL/6Smoc-Angptl3tm2(hANGPTL3)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210037
Validation Data：Presence

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(4)(Stock No.NM-HU-210036) mice function similarly to hANGPTL3(3) mice, for more detailed information please contact our technical advisor.

Mice

Ldoc1-KO

Strain Name：C57BL/6Smoc-Ldoc1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-252160

The exon 1 of Ldoc1 gene was deleted to generate Ldoc1 knockout mouse. This gene overlaps with the ENSMUSG00000124784(lncRNA) gene at the genomic locus and may impact the function of the overlapping gene.

Mice

B6 DIO

Strain Name：C57BL/6Smoc DIO
Strain State：Repository Live | Cat. NO.：SM-021

Diet-induced obesity (DIO) models are similar to human obesity, can effectively reflect the pathogenesis of human obesity, and are useful for studying metabolic diseases such as obesity, diabetes, and fatty liver disease.

Mice

Cd2-2A-CreERT2

Strain Name：C57BL/6Smoc-Cd2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18017
Validation Data：Presence

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Cd2 gene via homologous recombination to establish a tamoxifen inducible Cd2-CreERT2 tool stain. This strain can be used to knockout target gene in T cells and B cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sortm1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

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