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Models

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Mice

Prl-IRES-CreERT2

Strain Name：C57BL/6Smoc-Prlem1(IRES-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200170

A IRES-CreERT2 expression cassette was knocked into the Prl gene stop codon site. Prolactin (PRL) is a hormone synthesized and secreted by lactotroph cells in the anterior pituitary gland. PRL is responsible for lactogenesis and other processes associated with it. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

Mice

Spink4-Flox/Cdh1-Flox/R26-CAG-LSL-hRHOA*Y42C-IRES-tdTomato

Strain Name：C57BL/6Smoc-Spink4em1(flox)Cdh1tm(flox)1Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-LSL-RHOA(Y42C)-IRES-tdTomato-WPRE-polyA)Smoc
Strain State：Developing | Cat. NO.：NM-XA-241822

The Spink4-Flox(NM-CKO-234485) was crossed with Cdh1-Flox(NM-CKO-18016) and R26-CAG-LSL-hRHOA*Y42C-IRES-tdTomato(NM-KI-200048) to generate Spink4-Flox/Cdh1-Flox/R26-CAG-LSL-hRHOA*Y42C-IRES-tdTomato mice.

Mice

a-IRES-Cre

Strain Name：C57BL/6Smoc-atm1(Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200027

A IRES-Cre expression cassette was knocked into the a gene stop codon site via ESC targeting. Male mice with a germline Cre leak expression condition, please use female mice and flox mice for breeding crosses. References are available, please see the website for details.

Mice

Wnt1-Dre

Strain Name：C57BL/6Smoc-Wnt1em1(Dre-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200176

A Dre-Wpre-polyA expression cassette was knocked into the Wnt1 gene start codon site. Wnt1 gene is involved in stem cell poliferation in multiple systems, including the hematopoietic system and the embryonic nervous system. This strain may be useful for studying central nervous system development. When crossed with a strain carrying a gene flanked by rox sites, the flanked gene will be removed in cells expressing dre.

Mice

hSIRPA(2)/hCD47/hPD-1/hPD-L1(2)

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)Pdcd1em1(hPDCD1)Cd274em2(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220029

hSIRPA(2)(NM-HU-18015), hCD47(NM-HU-00050) and hPD-1(NM-HU-00015) was crossed with hPD-L1(2)(NM-HU-190039）to generate hSIRPA(2)/hCD47/hPD-1/hPD-L1(2) mice.

Mice

R26-CAG-LSL-hNRF2-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-NRF2-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18050

A SA-2xpolyA-CAG-LSL-human NRF2-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase to express human NRF2 and a reporter gene in certain cells or tissues that expressing Cre recombinase.

Mice

Foxp3-V5-AviTag-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Foxp3em1(V5-AviTag-IRES-luci-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18034

A V5-AviTag-IRES-luci-2A-tdTomato expression cassette was inserted before the stop codon TGA of mouse Foxp3 gene to establish a multi-labeled knockin model with V5, Avi, luciferase and tdTomato fluorescent protein.

Mice

h4-1BB(2)/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210357

h4-1BB(2)(NM-HU-190077), hPD-L1(NM-HU-00062) and hPD-1(NM-HU-00015) was crossed together to generate h4-1BB(2)/hPD-1/hPD-L1 mice.

Mice

hANGPTL3(4)

Strain Name：C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210036

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

hANGPTL3(3)

Strain Name：C57BL/6Smoc-Angptl3em2(hANGPTL3)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210037

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(4)(Stock No.NM-HU-210036) mice function similarly to hANGPTL3(3) mice, for more detailed information please contact our technical advisor.

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