Therapeutic Target-Humanized Mice
Cre/Dre-Driver Mice
Immunodeficient NMG Mice
Strain Name：C57BL/6Smoc-Fcgrtem2(hFCGRT)Smoc Strain State：Repository Live | Cat. NO.：NM-HU-190070
The endogenous mouse Fcgrt gene was replaced by human FCGRT gene.While hFCRN(Stock No.NM-HU-00109) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN(2) mice,for more detailed information please contact our technical advisor.
Strain Name：C57BL/6Smoc-Duxem1Smoc Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-242098
The Gm19459 gene, Gm4981 gene, Duxf3 gene, Gm10807 gene and AW822073 gene were deleted to generate Dux gene cluster knockout mouse.
Strain Name：C57BL/6Smoc-Csf2em2Smoc Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190532
Exon 1-3 of Csf2 gene was deleted to generate Csf2 knockout mice. Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality (Note from MGI).
Strain Name：C57BL/6Smoc-Csf2em3Smoc Strain State：Repository Live | Cat. NO.：NM-KO-226131
exon 1-2 of Csf2 gene was deleted to generate Csf2 knockout mice. Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality (Note from MGI).
Strain Name：BALB/cAnSmoc-Sirpatm(hSIRPA)Rag2em1IL2rgem1Smoc Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234081
On the basis of strain hSIRPA(BALB/c,2), Rag2 and Il2rg gene exon3 and Il2rg gene exon2 were knocked out to establish Rag2 and IL2RG gene knockout mouse models in hSIRPA(BALB/c,2) background.
Strain Name：C57BL/6Smoc-Col2a1em1(2A-CreERT2)Smoc Strain State：Repository Live | Cat. NO.：NM-KI-18029
A 2A-CreERT2 expression cassette was knocked into the stop codon of Col2a1 gene to establish a Col2a1-CreERT2 recombinase tool mouse.The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.
Strain Name：C57BL/6Smoc-Igkjem1Smoc Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191196
Igkj1, Igkj2, Igkj3, Igkj4, Igkj5 and Igkc were deleted to generate Igkj knockout mice.
Strain Name：C57BL/6Smoc-Crhem1(IRES-iCre-pA)Smoc Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200104
A IRES-iCre-pA expression cassette was knocked into the Crh gene stop codon site. This strain exhibits ectopic expression, and its expression profile requires validation.
Strain Name：C57BL/6Smoc-Sox10em(2A-Cre)Smoc Strain State：Repository Live | Cat. NO.：NM-KI-220066
2A-Cre expression cassette was knocked into the Sox10 gene stop codon site. The target gene is associated with pigment, and heterozygotes are recommended for mating in breeding.
Strain Name：C57BL/6Smoc-Col1a1em1(IRES-EGFP-IRES-MerCreMer)Smoc Strain State：Repository Live | Cat. NO.：NM-KI-240492
The IRES-EGFP-IRES-MerCreMer expression cassette was knocked into the Col1a1 gene stop codon site. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.
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