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Mice

Col2a1-2A-CreERT2

Strain Name：C57BL/6Smoc-Col2a1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18029

A 2A-CreERT2 expression cassette was knocked into the stop codon of Col2a1 gene to establish a Col2a1-CreERT2 recombinase tool mouse.The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

Igkj-KO

Strain Name：C57BL/6Smoc-Igkjem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191196

Igkj1, Igkj2, Igkj3, Igkj4, Igkj5 and Igkc were deleted to generate Igkj knockout mice.

Mice

Sox10-2A-Cre

Strain Name：C57BL/6Smoc-Sox10em(2A-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-220066

2A-Cre expression cassette was knocked into the Sox10 gene stop codon site. The target gene is associated with pigment, and heterozygotes are recommended for mating in breeding.

Mice

Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Cd8aem1(V5-IRES-luci-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18030

A V5-IRES-luci-2A-EGFP expression cassette was inserted before the stop codon TAA of mouse Cd8a gene to establish a multi-labeled knockin model with V5, luciferase and EGFP fluorescent protein.

Mice

hTNFR2/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220041

hTNFRSF1B(NM-HU-190010)，hPD-1(NM-HU-00015) and hPD-L1(NM-HU-00062) were crossed together to generate hTNFRSF1B/hPD-1/hPD-L1 mice.

Mice

hLAIR1/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Lair1em2(LAIR1)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220040

hLAIR1(NM-HU-2000011)，hPD-1(NM-HU-00015) and hPD-L1(NM-HU-00062) were crossed tegother to generate hLAIR1/hPD-1/hPD-L1 mouse.

Mice

hFCRN(3)

Strain Name：C57BL/6Smoc-Fcgrttm3(hFCGRT)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000032

The endogenous mouse Fcgrt gene was replaced by human FCGRT gene. While hFCRN(Stock No.NM-HU-00109）and hFCRN(2)(Stock No.NM-HU-190070) mice function similarly to hFCRN(3) mice,for more detailed information please contact our technical advisor.

Mice

R26-CAG-LSL-Luc-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-luci-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18051

A CAG-loxP STOP-loxP-luci-2A-tdTomato-WPRE-polyA cassette was knocked into the mouse ROSA26 locus . This strain of mice can be mated with mice expressing Cre recombinase so that luciferase and tdTomato fluorescent protein could be expressed for cell tracing.

Mice

Prom1-CreERT2

Strain Name：C57BL/6Smoc-Prom1em1(CreERT2-PolyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200169

A CreERT2-PolyA expression cassette was knocked into the Prom1 gene start codon site. Prom1 encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. When these Prom1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Prom1 expressing cells.

Mice

Zbtb46-IRES-Cre

Strain Name：C57BL/6Smoc-Zbtb46em1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200096

A  IRES-iCre expression cassette was knocked into the Zbtb46 gene stop codon site. This strain carries a significant risk of reproductive system leakage. Avoid using homozygotes and female Cre mice. It is recommended to use male mice, as they have a lower probability of leakage. After mating, offspring should be genotyped and promptly checked for any occurrence of reproductive leakage.

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