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Models

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Mice

hIL23A(DBA/1)

Strain Name：DBA/1-Il23atm3(hIL23A)Smoc
Strain State：Developing | Cat. NO.：NM-HU-240255

Strain derived from the backcross of hIL23A(NM-HU-18030)mice and DBA/1 mice.

Mice

Trpv2-Flox

Strain Name：B6;129S-Trpv2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00023

Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection.

Mice

hTNFa-Tg(DBA/1)

Strain Name：DBA/1-Tgtn(hTNFa promoter-hTNFa-pA)Smoc
Strain State：Developing | Cat. NO.：NM-TG-240240

Strain derived from the backcross of hTNFa-Tg(NM-TG-200004)mice and DBA/1 mice.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429
Validation Data：Presence  |  Publications：2piece

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

Krt14-KO

Strain Name：C57BL/6Smoc-Krt14em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00072

A total of 384 nucleotides were removed, including 5'UTR, ATG the start codon and part of the coding sequece.

Mice

Mirc34-KO

Strain Name：B6;129S-Mir449atm1Mir449btm1Mir449ctm1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00164

MicroRNA cluster 34 (Mirc34), including Mir449a, Mir449b and Mir449c genes, were knocked out in this strain.

Mice

MHCII/H2-K1/H2-D1-KO

Strain Name：C57BL/6Smoc-MHCⅡemH2-K1emH2-D1emSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-220166

MHCⅡ(I-A/I-E), H2-K1, and H2-D1 were deleted to generate MHCⅡ/H2-K1/H2-D1 knockout mice.

Mice

Col1a1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Col1a1em(IRES-CreERT2)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225031
Validation Data：Presence

IRES-CreERT2 expression cassette was knocked into the Col1a1 gene. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

FcγR-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgr2bemFcgr3emFcgr4emFcer1gem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-252414

By knocking out exon1-8 of the Fcgr2b gene, exon1-5 of the Fcgr3 gene, and exon1-5 of the Fcgr4 gene, and introducing mutations into exon 1 of the Fcer1g gene, Fcgr2b, Fcgr3, Fcgr4, and Fcer1g gene knockout mouse models were established.

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