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Models

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Mice

Trpv2-Flox

Strain Name：B6;129S-Trpv2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00023

Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection.

Mice

hTNFa-Tg(DBA/1)

Strain Name：DBA/1-Tgtn(hTNFa promoter-hTNFa-pA)Smoc
Strain State：Developing | Cat. NO.：NM-TG-240240

Strain derived from the backcross of hTNFa-Tg(NM-TG-200004)mice and DBA/1 mice.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

MHCII/H2-K1/H2-D1-KO

Strain Name：C57BL/6Smoc-MHCⅡemH2-K1emH2-D1emSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-220166

MHCⅡ(I-A/I-E), H2-K1, and H2-D1 were deleted to generate MHCⅡ/H2-K1/H2-D1 knockout mice.

Mice

Krt14-KO

Strain Name：C57BL/6Smoc-Krt14em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00072

A total of 384 nucleotides were removed, including 5'UTR, ATG the start codon and part of the coding sequece.

Mice

Mirc34-KO

Strain Name：B6;129S-Mir449atm1Mir449btm1Mir449ctm1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00164

MicroRNA cluster 34 (Mirc34), including Mir449a, Mir449b and Mir449c genes, were knocked out in this strain.

Mice

Fcgr2b/Fcgr3/Fcgr4/Fcer1g-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgr2bemFcgr3emFcgr4emFcer1gem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-252414

By knocking out exon1-8 of the Fcgr2b gene, exon1-5 of the Fcgr3 gene, and exon1-5 of the Fcgr4 gene, and introducing mutations into exon 1 of the Fcer1g gene, Fcgr2b, Fcgr3, Fcgr4, and Fcer1g gene knockout mouse models were established.

Mice

Col1a1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Col1a1em(IRES-CreERT2)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225031

IRES-CreERT2 expression cassette was knocked into the Col1a1 gene. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

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