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Models

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Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

Krt14-KO

Strain Name：C57BL/6Smoc-Krt14em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00072

A total of 384 nucleotides were removed, including 5'UTR, ATG the start codon and part of the coding sequece.

Mice

Mirc34-KO

Strain Name：B6;129S-Mir449atm1Mir449btm1Mir449ctm1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00164

MicroRNA cluster 34 (Mirc34), including Mir449a, Mir449b and Mir449c genes, were knocked out in this strain.

Mice

MHCII/H2-K1/H2-D1-KO

Strain Name：C57BL/6Smoc-MHCⅡemH2-K1emH2-D1emSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-220166

MHCⅡ(I-A/I-E), H2-K1, and H2-D1 were deleted to generate MHCⅡ/H2-K1/H2-D1 knockout mice.

Mice

hFCRN(2)

Strain Name：C57BL/6Smoc-Fcgrtem2(hFCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190070

The endogenous mouse Fcgrt gene was replaced by human FCGRT gene.While hFCRN(Stock No.NM-HU-00109) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN(2) mice,for more detailed information please contact our technical advisor.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Dux-KO

Strain Name：C57BL/6Smoc-Duxem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-242098

The Gm19459 gene, Gm4981 gene, Duxf3 gene, Gm10807 gene and AW822073 gene were deleted to generate Dux gene cluster knockout mouse.

Mice

Csf2-KO

Strain Name：C57BL/6Smoc-Csf2em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190532

Exon 1-3 of Csf2 gene was deleted to generate Csf2 knockout mice. Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality (Note from MGI).

Mice

Csf2-KO(2)

Strain Name：C57BL/6Smoc-Csf2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-226131

exon 1-2 of Csf2 gene was deleted to generate Csf2 knockout mice. Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality (Note from MGI).

Mice

Rag2/Il2rg-KO/hSIRPA(BALB/c,2)

Strain Name：BALB/cAnSmoc-Sirpatm(hSIRPA)Rag2em1IL2rgem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234081

On the basis of strain hSIRPA(BALB/c,2), Rag2 and Il2rg gene exon3 and Il2rg gene exon2 were knocked out to establish Rag2 and IL2RG gene knockout mouse models in hSIRPA(BALB/c,2) background.

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