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Models

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Mice

hIL2/hIL2RB/hIL2RG

Strain Name：C57BL/6Smoc-Il2rgem1(IL2RG)Il2tm3(hIL2)Il2rbtm1(hIL2RB)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220145

hIL2RG(NM-HU-200007) and IL2RB(NM-HU-2000055) mice were crossed with hIL2(NM-HU-190048) mice to generate hIL2/hIL2RB/hIL2RG mice.

Mice

hGDF15/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Gdf15em1(hGDF15)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220151

hGDF15(NM-HU-215002) and hPD-1(NM-HU-00015)mice were crossed with hPD-L1(NM-HU-00062) mice to generate hIL2/hIL2RB/hIL2RG mice.

Mice

hPD-1/hPD-L1(2)/hCCR8

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em2(hPD-L1)Ccr8em1(hCCR8)/Smoc
Strain State：Developing | Cat. NO.：NM-HU-210402

hPD-1(NM-HU-00015) and hPD-1(2)(NM-HU-190039) were crossed with hCCR8(NM-HU-190053) to generate hPD-1/hPD-L1(2)/hCCR8 mice.

Mice

IgI/Ighj/Igkj-KO

Strain Name：C57BL/6Smoc-Iglem1Ighjem1Igkjem1/Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210395

Igl-KO(NM-KO-191198) and Igkj-KO(NM-KO-191196) were crossed with Ighj-KO(NM-KO-191197) to generate IgI/Ighj/Igkj-KO mice.

Mice

Il18-3×FLAG-NLS-mNeongreen-NLS-6×HIS

Strain Name：C57BL/6Smoc-Il18em1(3×FLAG-NLS-mNeongreen-NLS-6×HIS)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-233874

The 3×FLAG-NLS-mNeongreen-NLS-6×HIS expression cassette was substituted for the sequence between the start and stop codons of the Il18 gene.

Mice

Sprr2a-KO

Strain Name：C57BL/6Smoc-Sprr2a1emSprr2a2emSprr2a3em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-241703

The exon 1-exon 2 of Sprr2a1, exon 1-exon 2 of Sprr2a2 and exon 1-exon 2 of Sprr2a3 genes were deleted to generate Sprr2a1, Sprr2a2 and Sprr2a3 knockout mouse.

Mice

Clec18a-Flox

Strain Name：B6;129S-Clec18atm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00006

These mice possess loxP sites on either side of exon 5 of C-type lectin domain family 18 member A gene and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain,this strain is useful in eliminating tissue-specific con

Mice

Cdkn2a/Cdkn2b-Flox(p15/p16/p19-Flox)

Strain Name：C57BL/6Smoc-Cdkn2a/Cdkn2bem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-235093

The p15/p16/p19-Flox mouse model was obtained by inserting a loxp site upstream of the Cdkn2b gene exon 1 and another loxP site downstream of the Cdkn2a(p16) gene exon 1. The flox region of these strains contains the entire genomic region between exon1 of the p15 gene and exon1 of the p16 gene.

Mice

Cdkn2a/Cdkn2b-KO(p15/p16/p19-KO)

Strain Name：C57BL/6Smoc-Cdkn2aemCdkn2bem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-241617

The p15/p16/p19-KO mouse model was established by knocking out all genomic regions between exon1 of the p15 gene and exon1 of the p16 gene.

Mice

Il1b-Luc-Tg

Strain Name：B6.Cg-Tg(IL1B-luc)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00001

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

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