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Models

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Mice

Col1a1-tetO-EML4-ALK

Strain Name：C57BL/6Smoc-Col1a1tm1(TetO-EML4-ALK)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：DM-KI-251860

The human EML4-ALK gene was cloned into a TetO-EML4-ALK construct and microinjected into FVB zygotes, where it was inserted into the mouse Col1a1 locus. This strain was donated by the laboratory of Academician Liang Chen at Jinan University. Any published research papers or other forms of literature should cite: "Zhou Q, Yang T, Yu X, et al. Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity. EMBO Mol Med. 2025;17(3):563-588. doi:10.1038/s44321-025-00200-y"

Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013
Validation Data：Presence

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

Mice

hIl5

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190001
Validation Data：Presence

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.

Mice

hAPOE4

Strain Name：C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002
Validation Data：Presence

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoetm3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003
Validation Data：Presence

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

hHBA

Strain Name：C57BL/6Smoc-Hba-x/Hba-a1tm1(hHBA1/hHBA2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-253362

By using homologous recombination, the mouse Hba-x and Hba-a1 genes were modified for humanization (the human genes being: HBA1 and HBA2).

Mice

hβA

Strain Name：C57BL/6Smoc-Hbb-bs＆Hbb-bttm1(hHBG1，hHBB)Smoc
Strain State：Developing | Cat. NO.：NM-HU-253365

By using homologous recombination, the mouse Hbb-bs and Hbb-bt genes were subjected to humanization modification (the human genes being: HBA1 and HBA2).

Mice

hβS

Strain Name：C57BL/6Smoc-Hbb-bs＆Hbb-bttm1(hHBG1,hHBB-E7V)Smoc
Strain State：Developing | Cat. NO.：NM-HU-253366

By using homologous recombination, the mouse Hbb-bs and Hbb-bt genes were subjected to humanization modification (the human genes being: HBG1 and HBB).

Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

Abi3bp-Flox

Strain Name：B6;129S-Abi3bptm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00009

An frt-neo-frt cassette was inserted before exon 4. And these mice possess loxP sites on either side of exon 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

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