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Models

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Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

Atg5-KO

Strain Name：C57BL/6Smoc-Atg5em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18004

Exon3 of Atg5 gene was targeted and a additional 58bp sequence insertion caused a frameshift mutation.

Mice

Chrna7/Fan1-KO

Strain Name：C57BL/6Smoc-Chrna7em1(Del1263751bp)Fan1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18062

Exon 1-9 of Chrna7 gene and exon 5-14 of Fan1 gene were deleted to generate Chrna7/Fan1-KO mice.

Mice

Cd1d1/Cd1d2-KO

Strain Name：C57BL/6Smoc-Cd1d1em1Cd1d2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-202158

Exon 1-6 of Cd1d1 gene and exons 1-7 of Cd1d2 gene was deleted to generate Cd1d1 and Cd1d2 double knockout mice.

Mice

Abcb1a/Abcb1b-KO(FVB)

Strain Name：FVB-Abcb1aem1Abcb1bem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-191211

All sequences between exon2 of Abcb1a gene and exon28 of Abcb1b gene were knocked out by CRISPR/Cas9 technology.

Mice

Rest-Flox

Strain Name：B6;129S-Resttm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-00001

These mice possess loxP sites in intron1 and intron2 of Rest gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Mir29a/Mir29b1-KO

Strain Name：C57BL/6Smoc-Mir29aem1 Mir29b-1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-00081

a 0.6kb region in length including Mir29a and Mir29b-1 pre-microRNAs was removed in this strain.

Mice

Resp18-KO

Strain Name：B6;129S-Resp18tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00022

These Resp18 knockout mice were established technology and crossed with FLP transgenic mice to delete PGK-Neo gene.

Mice

Tfpi2-Flox

Strain Name：B6;129S-Tfpi2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00117

A loxp-IRES-GFP-reverse loxp cassette and an frt-Neo-frt cassette were inserted in intron 2 of Tfpi2 gene. After crossed with Cre transgenic mice, Tfpi2 gene is supposed to be knocked out and labeled by GFP simultaneously.

Mice

Alb-CreERT2

Strain Name：B6.129S-Albtm1.1(CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00002

Exons 1-7 were replaced by CreERT2 and a loxp neo casette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.This strain has removed the Neo screening gene.

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