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TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma

Model Organisms：小鼠 Product & Service：Trem2-KO Research field：hepatocellular carcinoma

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases

Model Organisms：小鼠 Product & Service：Tlr2-KO;Cd45.1;Rag2-KO Research field：autoimmune diseases

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

Model Organisms：小鼠 Product & Service：- Research field：

Targeting long noncoding RNA-AQP4-AS1 for the treatment of retinal neurovascular dysfunction in diabetes mellitus

Model Organisms：小鼠 Product & Service：Aqp4-KO Research field：Diabetic retinopathy

Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation

Model Organisms：Zebrafish Product & Service：- Research field：snailfish

A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both...

Model Organisms：小鼠 Product & Service：Zap70-W163C Research field：Ankylosing Spondylitis

Conditional RNA interference achieved by Oct-1 POU/rtTA fusion protein activator and a modified TRE-mouse U6 promoter

Model Organisms：细胞 Product & Service：Palld Research field：Method

可逆性调节RNA干扰

Discovery of Novel CA-4 Analogs as Dual Inhibitors of Tubulin Polymerization and PD-1/PD-L1 Interaction for Cancer...

Model Organisms：Mouse Product & Service：PD-1 Research field：Cancer Treatment

Webinar on Advances in Antibody-Drug Conjugates (ADCs) Development & Preclinical Models

Antibody-Drug Conjugates ADC Development Preclinical Models Targeted Cancer Therapies GenoBioTX ADC Webinar Biopharma Research Oncology Biochemistry Cancer Treatment Preclinical Evaluation Monoclonal Antibodies Small Molecule Drugs

Join us for a webinar on June 26th, 2024, exploring the development and preclinical evaluation of Antibody-Drug Conjugates (ADCs). Learn from Dr. Hua Wei, VP of the Industrial Clients Department at GenoBioTX, about ADC components, mechanisms, historical evolution, and future directions.

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.