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About 199 results
Mice

Ern1-Flox

Strain Name：B6;129S-Ern1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00077
Publications：1piece

An frt-neo-frt cassette was inserted after exon 2 and loxP sites was inserted before exon 2 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of t

Mice

Tmem173-Flox

Strain Name：B6;129S-Tmem173tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-00014
Publications：1piece

An frt-neo-frt cassette was inserted after exon 4 and a loxP sites was putted before exon 2 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of t

Mice

Vwc2l-Flox

Strain Name：B6;129S-Vwc2ltm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00005

An frt-neo-frt cassette was inserted after exon 2 and a loxP sites was putted before exon 2 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of t

Mice

Sema3g-Flox

Strain Name：B6;129S-Sema3gtm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00068

An frt-neo-frt cassette was inserted after exon 4 and a loxP sites was putted before exon 2 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of t

Mice

NOD SCID

Strain Name：NOD.Cg-Prkdcscid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Mice

Wt1-Flox

Strain Name：C57BL/6Smoc-Wt1tm3(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200041

These mice carry loxP sites flanking exon 2-3 of Wt1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Wt1 gene.While Wt1-Flox(Stock No.NM-CKO-200234）mice carrying t

Mice

Gba-Flox(2)

Strain Name：C57BL/6Smoc-Gbaem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200179

These mice carry loxP sites flanking exon 6-8 of Gba gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gba gene.While Gba-Flox(Stock No.NM-CKO-200051)mice carrying t

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070
Validation Data：Presence

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Col1a1-tetO-EML4-ALK

Strain Name：C57BL/6Smoc-Col1a1tm1(TetO-EML4-ALK)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：DM-KI-251860

The human EML4-ALK gene was cloned into a TetO-EML4-ALK construct and microinjected into FVB zygotes, where it was inserted into the mouse Col1a1 locus. This strain was donated by the laboratory of Academician Liang Chen at Jinan University. Any published research papers or other forms of literature should cite: "Zhou Q, Yang T, Yu X, et al. Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity. EMBO Mol Med. 2025;17(3):563-588. doi:10.1038/s44321-025-00200-y"

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