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Pten-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg

Strain Name：Pten-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg
Strain State ： Validation of target gene expression completed |  Cat. NO.：NMC-250228

Pancreatic cancer cell line（Pten-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg）

Trp53-KO/Kras-G12D

Strain Name：Trp53-KO/Kras-G12D
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD08

Trp53-KO/Kras-G12D cell line is murine cell derived from lung cancer model of the offspring produced by mating Trp53-Flox mice (NM-CKO-18005) and Kras-LSL-G12D mice (NM-KI-190003).

Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg

Strain Name：Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD13

Derived from Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg mice(NM-XA-234939) spontaneous lung cancer model

R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c)

Strain Name：R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c)
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD15

Derived from R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c) mice(NM-KI-200324) spontaneous lung cancer model

The Kruppel-associated box repressor domain induces reversible and irreversible regulation of endogenous mouse genes...

Model Organisms：小鼠 Product & Service：Hprt Research field：Method

KRAB

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

Model Organisms：小鼠 Product & Service：- Research field：

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

GEMM-Derived Allografts

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.