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Models

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Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001
Validation Data：Presence

Prkdc and Il2rg genes were both knocked-out in NOD mice. Lacking mature T, B and NK cells; Low immune rejection against human cells and tissues; Good tumorigenicity so that a small number of cells can form tumors; Significant improvement in the survival of transplanted human cells and tissues; Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models; Suitable as the carrier mice for the transplantation of heterologous cells and tissues.

Mice

hIL2RG

Strain Name：C57BL/6Smoc-Il2rgtm1(IL2RG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200007

The endogenous mouse Il2rg gene was replaced by human IL2RG gene.

Mice

hIL2RG/hIL2RB

Strain Name：C57BL/6Smoc-Il2rgtm1(IL2RG)Il2rbtm1(hIL2RB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210354
Validation Data：Presence

hIL2RG(NM-HU-200007) was crossed with hIL2RB(NM-HU-2000055) to generate hIL2RG/hIL2RB mice.

Mice

Adgra2-Flox

Strain Name：B6;129S-Adgra2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00101

These Gpr124 flox mutant mice possess loxP sites flanking exon 2 of the G protein-coupled receptor 124 (Gpr124) targeted gene. Homozygotes are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

Mice

Il2rg-KO

Strain Name：C57BL/6Smoc-Il2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210098

Exon 2 of Il2rg gene was deleted to generate Il2rg knockout mice.

Mice

Il2rg-Flox

Strain Name：C57BL/6Smoc-Il2rgem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-251630

These mice carry loxP sites flanking exon 1-5 of Il2rg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il2rg gene.

Mice

Htr1a-KO

Strain Name：C57BL/6Smoc-Htr1Aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190594

Exon 1 of Htr1a gene was deleted to generate Htr1a knockout mice.

Mice

Cebpg-Flox

Strain Name：C57BL/6Smoc-Cebpgem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-241154

These strains carry loxP sites flanking exon 2 of Cebpg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cebpg gene.

Mice

Cebpg-KO

Strain Name：C57BL/6Smoc-Cebpgem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201465

Exon 2 of Cebpg gene was deleted to generate Cebpg knockout mice.

Mice

hSIGLEC10

Strain Name：C57BL/6Smoc-Siglecgtm1(hSIGLEC10)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000061
Validation Data：Presence

The endogenous mouse Siglecg gene was replaced by human SIGLEC10 gene.

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