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Models

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Mice

Gna11-Flox

Strain Name：C57BL/6Smoc-Gna11em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-205090

These mice carry loxP sites flanking exon 2 of Gna11 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gna11 gene.

Mice

Gna11-KO

Strain Name：C57BL/6Smoc-Gna11em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 2 of Gna11 gene was deleted to generate Gna11 knockout mice.

Mice

Gucy2g-Flox

Strain Name：C57BL/6Smoc-Gucy2gem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Gucy2g gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gucy2g gene.

Mice

Gucy2G-KO

Strain Name：C57BL/6Smoc-Gucy2Gem1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 2 of Gucy2G gene was deleted to generate Gucy2G knockout mice.

Mice

hAppNL-G-F

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-G-F)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000088

The endogenous mouse App gene was replaced by human AppNL-G-F.

Mice

Lepr-g.G109052T

Strain Name：B6.129S-Leprtm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00001

A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.

Mice

hAppNL-G-F/Mapt-hMAPT-P301S/hAPOE4

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-G-F)Maptem1hMAPT-P301SApoetm2(hAPOE4)Smoc
Strain State：Developing | Cat. NO.：NM-XA-240813

The Mapt-hMAPT-P301S/hAPOE4(NM-XA-240812) was crossed with hAppNL-G-F(NM-HU-2000088) to generate hAppNL-G-F/Mapt-hMAPT-P301S/hAPOE4 mice.

Mice

hHLA-G/B2M

Strain Name：C57BL/6Smoc-B2mem1(hB2M-2A-HLA-G)Smoc
Strain State：Developing | Cat. NO.：NM-HU-241967

The endogenous mouse B2m gene was replaced by human B2M/HLA-G gene.

Mice

hAppNL-G-F/hAPOE4

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-G-F)Apoetm2(hAPOE4)Smoc
Strain State：Developing | Cat. NO.：NM-XA-250109

The hAPOE4(NM-HU-190002) was crossed with hAppNL-G-F(NM-HU-2000088) to generate hAppNL-G-F/hAPOE4 mice.

Mice

Mapt-hMAPT-P301S/hAppNL-G-F

Strain Name：C57BL/6Smoc-Maptem1hMAPT-P301SApptm3(hAppNL-G-F)Smoc
Strain State：Developing | Cat. NO.：NM-XA-250110

The hMAPT-P301S(NM-KI-233262) was crossed with hAppNL-G-F(NM-HU-2000088) to generate Mapt-hMAPT-P301S/hAppNL-G-F mice.

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