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Models

About 103 results
Mice

Foxp3-IRES-tdTomato-2A-Cre

Strain Name：C57BL/6Smoc-Foxp3em3(IRES-tdTomato-2A-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190119
Validation Data：Presence

A IRES-tdTomato-2A-Cre expression cassette was knocked into the Foxp3 gene stop codon site. This strain is useful in studying regulatory T cell in autoimmunity, especially in type 1 diabetes.

Mice

NOD SCID

Strain Name：NOD.Cg-Prkdcscid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Mice

B6 DIO

Strain Name：C57BL/6Smoc DIO
Strain State：Repository Live | Cat. NO.：SM-021

Diet-induced obesity (DIO) models are similar to human obesity, can effectively reflect the pathogenesis of human obesity, and are useful for studying metabolic diseases such as obesity, diabetes, and fatty liver disease.

Mice

Cpe-KO

Strain Name：C57BL/6Smoc-Cpeem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190671

Exon 2 of Cpe gene was deleted to generate Cpe knockout mice.

Mice

Iapp-KO

Strain Name：C57BL/6Smoc-Iappem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190664

Exon 3 of Iapp gene was deleted to generate Iapp knockout mice.

Mice

Adipor2-KO

Strain Name：C57BL/6Smoc-Adipor2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190667

Exon 3-4 of Adipor2 gene was deleted to generate Adipor2 knockout mice.

Mice

Mapk8-KO

Strain Name：C57BL/6Smoc-Mapk8em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190836

Exon 3 of Mapk8 gene was deleted to generate Mapk8 knockout mice.

Mice

Atxn2-KO

Strain Name：C57BL/6Smoc-Atxn2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190920

Exon 6 of Atxn2 gene was deleted to generate Atxn2 knockout mice.

Mice

Fto-Flox

Strain Name：C57BL/6Smoc-Ftoem3(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-190005

These mice carry loxP sites flanking exon3 of Fto gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Fto gene.

Mice

R26-CAG-LSL-Fto-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-3xFLAG-Fto-IRES-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190055

These mice harbor a CAG-LSL-3xFLAG-Fto-IRES-EGFP cassette in the Rosa26 locus generated by homologous recombination.

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