Welcome to Advanced Search

Models

About 21,252 results
Mice

E2f1-Flox

Strain Name：C57BL/6Smoc-E2f1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of E2f1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of E2f1 gene.

Mice

Slc6a8-Flox

Strain Name：C57BL/6Smoc-Slc6a8em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-240704

These strains carry loxP sites flanking exon 2-4 of Slc6a8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Slc6a8 gene.

Mice

H2Afv-KO

Strain Name：C57BL/6Smoc-H2Afvem1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 2-4 of H2Afv gene was deleted to generate H2Afv knockout mice.

Mice

Hhat-Flox

Strain Name：C57BL/6Smoc-Hhatem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Hhat gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hhat gene.

Mice

H2afv-Flox

Strain Name：C57BL/6Smoc-H2afvem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of H2afv gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of H2afv gene.

Mice

A1cf-Flox

Strain Name：C57BL/6Smoc-A1cfem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-253742

These mice carry loxP sites flanking exon 4 of A1cf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A1cf gene.

Mice

A1Cf-KO

Strain Name：C57BL/6Smoc-A1Cfem1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 4 of A1Cf gene was deleted to generate A1Cf knockout mice.

Mice

Tppp3-Flox

Strain Name：B6;129S-Tppp3tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00085

These mice carry loxP sites flanking exons 2-4 of Tppp3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Upk3a-2A-GFPCre

Strain Name：C57BL/6Smoc-Upk3aem1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210003

2A-EGFP-Cre expression cassette was knocked into the Upk3a gene .

Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096
Validation Data：Presence

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Email Back to top