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Mice

Calb1-2A-GFPCre

Strain Name：C57BL/6Smoc-Calb1em1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200141
Validation Data：Presence

A 2A-EGFP-Cre expression cassette was knocked into the Calb1 gene stop codon site. Calb1 is highly expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful in studying many neurobehavioral diseases such as spatial learning and circadian rhythm interference. It has been reported that the incidence of many diseases may be different between genders.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025
Publications：1piece

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

Wt1-GFPCre

Strain Name：C57BL/6Smoc-Wt1em1(GFPCre-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200128
Validation Data：Presence

A GFPCre-WPRE-pA expression cassette was knocked into the Wt1 gene start codon site.

Mice

Clec4f-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Clec4fem1(IRES-DTRGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200070

A IRES-DTRGFP expression cassette was knocked into the Clec4f gene stop codon site.

Mice

Creb5-Flox

Strain Name：C57BL/6Smoc-Creb5em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2100204

These mice carry loxP sites flanking exon 6 of Creb5 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creb5 gene.

Mice

Crebbp-Flox

Strain Name：C57BL/6Smoc-Crebbptm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-190016

These mice carry loxP sites flanking exon7-8 of Crebbp gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crebbp gene.

Mice

Creb5-KO

Strain Name：C57BL/6Smoc-Creb5em/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-230258

The exon 6 of Creb5 gene was deleted to generate Creb5 knockout mice.

Mice

Creld2-Flox

Strain Name：C57BL/6Smoc-Creld2tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-232503

These strains carry loxP sites flanking exon 5-10 of Creld2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creld2 gene.

Mice

Crem-Flox

Strain Name：C57BL/6Smoc-Cremem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-242489

These strains carry loxP sites flanking exon 2-3 of Crem gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crem gene.

Mice

Creb1-Flox

Strain Name：C57BL/6Smoc-Creb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-250321

These strains carry loxP sites flanking exon 8 of Creb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creb1 gene.

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