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Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

Wt1-GFPCre

Strain Name：C57BL/6Smoc-Wt1em1(GFPCre-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200128

A GFPCre-WPRE-pA expression cassette was knocked into the Wt1 gene start codon site.

Mice

Clec4f-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Clec4fem1(IRES-DTRGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200070

A IRES-DTRGFP expression cassette was knocked into the Clec4f gene stop codon site.

Mice

Creb3l1-Flox

Strain Name：C57BL/6Smoc-Creb3l1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Creb3l1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creb3l1 gene.

Mice

Creld1-Flox

Strain Name：C57BL/6Smoc-Creld1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Creld1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creld1 gene.

Mice

Crebzf-Flox

Strain Name：C57BL/6Smoc-Crebzfem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Crebzf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crebzf gene.

Mice

Creg1-Flox

Strain Name：C57BL/6Smoc-Creg1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Creg1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creg1 gene.

Mice

Creb3l3-Flox

Strain Name：C57BL/6Smoc-Creb3l3em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Creb3l3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creb3l3 gene.

Mice

Creg2-Flox

Strain Name：C57BL/6Smoc-Creg2em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Creg2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creg2 gene.

Mice

Creb3l2-Flox

Strain Name：C57BL/6Smoc-Creb3l2em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Creb3l2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Creb3l2 gene.

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