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Mice

Lgr5-EGFP-IRES-CreERT2

Strain Name：C57BL/6Smoc-Lgr5em1(EGFP-IRES-creERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200154

A EGFP-IRES-creERT2-WPRE-polyA expression cassette was knocked into the Lgr5 gene start codon site.

Mice

Cdh5-rtTA-TetO-Cre

Strain Name：B6;129S-Cdh5tm1(rtTA-tetO-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18006

These mice harbor an M2rtTA-Wpre-polyA-attp-PGK-Neo-polyA-attb-long insulator-tetO-Cre-FRT-Wpre-FRT-polyA-long insulator cassette before ATG of the Cdh5 locus generated homologous recombination.

Mice

Nkx2-5-IRES-Cre

Strain Name：C57BL/6Smoc-Nkx2-5em1(IRES-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200152

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Nkx2-5 gene stop codon site.

Mice

Mki67-RSR-2A-Cre

Strain Name：C57BL/6-Mki67em(C-Rox-STOP-C-Rox-2A-Cre-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220093

C-Rox-STOP-C-Rox-2A-Cre-WPRE-pA expression cassette was knocked into the Mki67 gene stop codon site.

Mice

Foxp3-IRES-tdTomato-2A-CreERT2

Strain Name：C57BL/6Smoc-Foxp3em4(IRES-tdTomato-2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190120

A IRES-tdTomato-2A-CreERT2 expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

Stra8-2A-tdTomato-2A-Cre

Strain Name：C57BL/6Smoc-Stra8em(T2A-tdTomato-P2A-Cre)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225030

T2A-tdTomato－P2A－Cre expression cassette was knocked into the Stra8 gene .

Mice

Tnnt2-dCreERT2

Strain Name：C57BL/6Smoc-Tnnt2em1(rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200015

A rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA expression cassette was knocked into the Tnnt2 gene start codon site.

Mice

Tnni3-dCreERT2

Strain Name：C57BL/6Smoc-Tnni3em1(rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200014

A rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA expression cassette was knocked into the Tnni3 gene start codon site.

Mice

Calb1-2A-GFPCre

Strain Name：C57BL/6Smoc-Calb1em1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200141

A 2A-EGFP-Cre expression cassette was knocked into the Calb1 gene stop codon site. Calb1 is highly expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful in studying many neurobehavioral diseases such as spatial learning and circadian rhythm interference. It has been reported that the incidence of many diseases may be different between genders.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain explicitly states that fluorescence cannot be directly observed.

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