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Models

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Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6raem1(hIL6R)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hVEGFR2

Strain Name：C57BL/6Smoc-Kdrtm2(hKDR) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00098

The endogenous mouse Kdr gene was replaced by human KDR gene .

Mice

hTNFR2/hPD-1

Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210407

hTNFRSF1B(NM-HU-190010) was crossed with hPD-1（NM-HU-00015）to generate hTNFRSF1B/hPD-1 mice

Mice

Ctsk-2A-Cre

Strain Name：C57BL/6Smoc-Ctskem1(2A-Cre-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190019

The 2A-Cre-Wpre-polyA cassette is inserted before 3'UTR region of Ctsk gene.

Mice

Akt2-KO

Strain Name：C57BL/6Smoc-Akt2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190742

Exon 3-4 of Akt2 gene was deleted to generate Akt2 knockout mice.

Mice

hTIGIT/hTNFR2

Strain Name：C57BL/6Smoc-Tigittm3(hTIGIT)Tnfrsf1bem2(hTNFRSF1B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210371

hTIGIT(3)(NM-HU-200244) was crossed with hTNFRSF1B(NM-HU-190010）to generate hTIGIT(3)/hTNFRSF1B mice

Mice

A2m-Flox

Strain Name：C57BL/6Smoc-A2mem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of A2m gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A2m gene.

Mice

hSOST(2)

Strain Name：C57BL/6Smoc-Sostem1(hSOST)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215021

The endogenous mice Sost gene was replaced by human SOST gene. While hSOST(Stock No.NM-HU-200251) mice function similarly to hSOST(2) mice, for more detailed information please contact our technical advisor.

Mice

hCSF2

Strain Name：C57BL/6Smoc-Csf2tm1(CSF2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190046

The endogenous mouse Csf2 gene was replaced by human CSF2 gene.

Mice

hCLEC4C

Strain Name：C57BL/6Smoc-Dppa3tm1(hCLEC4C)Smoc
Strain State：Developing | Cat. NO.：NM-HU-225073

The human CLEC4C gene was knocked in the close location of the Dppa3 gene.

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