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Models

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Mice

Wt1-GFPCre

Strain Name：C57BL/6Smoc-Wt1em1(GFPCre-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200128
Validation Data：Presence

A GFPCre-WPRE-pA expression cassette was knocked into the Wt1 gene start codon site.

Mice

Wnt5b-IRES-CreERT2-2A-tdTomato

Strain Name：C57BL/6Smoc-Wnt5bem(IRES-CreERT2-P2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215083

IRES-CreERT2-P2A-tdTomato expression cassette was knocked into the Wnt5b gene .

Mice

hTLR9

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18016
Validation Data：Presence

This TLR9 humanized mouse model was established by replacing the mouse Tlr9 gene exon2 with the human TLR9 corresponding sequence by homologous recombination.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

H11-pAlb-hALB-IRES-Luc

Strain Name：C57BL/6Smoc-Igs2tm1(ALB promoter-human ALB-IRES-Luciferase-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200322

An ALB promoter-human ALB-IRES-Luciferase-polyA expression cassette was knocked into the H11 locus.

Mice

hCALCRL

Strain Name：C57BL/6Smoc-Calcrltm1(hCALCRL)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225031
Validation Data：Presence

The endogenous mouse Calcrl gene was replaced by human CALCRL gene.

Mice

Itgam-IRES-hCD89/hIGHA1

Strain Name：C57BL/6Smoc-Itgamtm1(IRES-hCD89-WPRE-polyA)sμtm1(hIGHA1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210412
Validation Data：Presence

Itgam-IRES-hCD89(NM-KI-200063) was crossed with hIGHA1(NM-HU-2000086) to generate Itgam-IRES-hCD89/hIGHA1 mice.

Mice

Wt1-CreERT2

Strain Name：C57BL/6Smoc-Wt1em1(CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200127
Validation Data：Presence

A CreERT2-WPRE-pA expression cassette was knocked into the Wt1 gene start codon site.

Mice

H11-CAG-LSL-ZsGreen-CAG-RSR-tdTomato

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-ZsGreen-wpre-pA-CAG-RSR-tdTomato-wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200319
Publications：1piece

A CAG-LSL-ZsGreen-wpre-pA-CAG-RSR-tdTomato-wpre-pA expression cassette was knocked into the H11 locus.

Mice

Braf-Flox

Strain Name：C57BL/6Smoc-Brafem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200073

These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene.

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