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Mice

HLA-B27.5/B2M(BALB/c)

Strain Name：BALB/c-B2mem1(hB2M-linker-HLA-B*2705/H2-D1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-260633

The endogenous mouse B2m gene was replaced by human B2M gene.

Mice

HLA-B27.5/B2M

Strain Name：C57BL/6Smoc-B2mem1(hB2M-linker-HLA-B*2705/H2-D1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-261003

The endogenous mouse B2m gene was replaced by human B2M gene.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001
Validation Data：Presence  |  Publications：59piece

Prkdc and Il2rg genes were both knocked-out in NOD mice. Lacking mature T, B and NK cells; Low immune rejection against human cells and tissues; Good tumorigenicity so that a small number of cells can form tumors; Significant improvement in the survival of transplanted human cells and tissues; Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models; Suitable as the carrier mice for the transplantation of heterologous cells and tissues.

Mice

Ebf1-Flox

Strain Name：B6;129S-Ebf1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00065

These mice carry loxP sites flanking exon 3 of the early B cell factor 1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Ighm/Ighd-KO

Strain Name：C57BL/6Smoc-Ighmem1Ighdem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200610
Validation Data：Presence

Exon 1-6 of Ighm and exon 1-5 of Ighd gene was deleted to generate Ighm and Ighd knockout mice. Homozygous mutant mice lack mature B cells. It may be useful as a model for B cell immunodeficiency found in humans.

Mice

Cd2-2A-CreERT2

Strain Name：C57BL/6Smoc-Cd2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18017
Validation Data：Presence

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Cd2 gene via homologous recombination to establish a tamoxifen inducible Cd2-CreERT2 tool stain. This strain can be used to knockout target gene in T cells and B cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

NOD SCID

Strain Name：NOD.Cg-Prkdcscid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070
Validation Data：Presence

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

SCID

Strain Name：CB17-Prkdcscid/Smoc
Strain State：Repository Live | Cat. NO.：SM-015
Validation Data：Presence

SCID mice, or severe combined immunodeficiency mice, were first identified in 1983 by Bosma M.J. in the United States from the C.B.-17/Icr inbred strain. This condition arises from a mutation in a single recessive gene located on chromosome 16, also termed the SCID gene. SCID mice constitute an inbred homozygous line of C.B-17/IcrJ, exhibiting white coat colouration. This strain displays severe combined immunodeficiency, characterised by the absence of B-cell and T-lymphocyte function. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA, and their thymus, lymph nodes, and splenic follicles contain almost no lymphocytes. However, the strain possesses normal NK cells, macrophages, and granulocytes. SCID mice are frequently used for inoculation with allogeneic or xenogeneic grafts, making them an ideal model for cell transplantation experiments.

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