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"Biomodel Organism" Holds Ceremony in Beijing to Celebrate Listing on NEEQ

On November 18, 2016, Shanghai Model Organisms Center, Inc. was listed on the NEEQ as follows. Stock Name: Biomodel Organism; Stock Code: 839728.

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

Applications of Animal Models

cell model animal model organism animal model

The model animal has played an important role in the history of life sciences and medicine, with a wide range of application in biology, medicine, molecular biology, molecular genetics, immunology and other fields.

Innovative Ab Drugs Development from target validation to IND application

Gene tracking

marker gene gene tracking

Gene tracers are an important application for genetically engineered mice. Through gene knock-in, exogenous tracer genes were knocked into endogenous genes, enabling labeling and tracing of genes.

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Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

Immunology and Inflammation

Inflammatory mouse

Shanghai Model Organisms provides a variety of mouse models of inflammation including exarteritis, chemotherapy-induced intestinal inflammation and inflammatory bowel disease. These models can be applied in researches on the mechanism of inflammation, evaluation of drug efficacy, and others.

Popular Model Organisms

genetically modified organisms transgenic organisms genetically modified organisms examples

Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

Study of Gene Functions

gene functions methods to study gene function what are the functions of genes