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Pah-KO

Strain Name：C57BL/6Smoc-Pah^em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-2110565
Validation Data：Presence

Exon 2-5 of pah gene was deleted to generate pah knockout mice. The homozygous (HO) mice have a certain mortality rate (approximately 15%). Heterozygous (HE) mice are recommended for colony establishment. If you need to purchase homozygous (HO) mice directly for experiments, it is recommended to purchase an additional 15%-20% to avoid mouse death affecting subsequent experiments.

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1^{em1(CreERT2-SV40-pA)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1^{em1(CreERT2-pA)Smoc}
Strain State：Repository Live | Cat. NO.：NM-KI-200123
Validation Data：Presence

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

NOD SCID

Strain Name：NOD.Cg-Prkdc^scid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Pdyn-IRES-Cre

Strain Name：C57BL/6Smoc-Pdyn^{em1(IRES-iCre)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200089
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Pdyn gene stop codon site. Pdyn encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying depression, stress, anxiety, pain response, circadian rhythm and appetite control.

App-KO(SD)

Strain Name：SD-App^em1Smoc Strain State：Embryo cryopreservation | Cat. NO.：NR-KO-210155

Exon3 of App gene was deleted to generate App knockout rats.

hAPP(SD)

Strain Name：SD-App^{em1(hAPP)Smoc} Strain State：Embryo cryopreservation | Cat. NO.：NR-HU-225062

The endogenous rat App gene was replaced by human APP gene.

hAPP mutation(SD)

Strain Name：SD-App^{tm1(hAPP mutation)Smoc} Strain State：Repository Live | Cat. NO.：NR-HU-225063
Validation Data：Presence

The endogenous rat App gene was replaced by human APP mutation gene.

Parkin overexpression ameliorates hippocampal long-term potentiation and beta-amyloid load in an Alzheimer's disease...

Model Organisms：小鼠 Product & Service：NSE-globin-parkin Research field：Nervous System

阿尔兹海默症 AD APP/PS1

Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue

Model Organisms：Mouse Product & Service：Ucp1-2A-GFP Research field：Obesity and fatty liver and other related metabolic diseases