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Models

About 117 results
Mice

Col4a5-R471X

Strain Name：C57BL/6Smoc-Col4a5em1(R471X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200183

These mice carry a R471X mutation of Col4a5 gene.

Mice

Dgcr2/Hira-KO

Strain Name：C57BL/6Smoc-Dgcr2em1Hiraem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18060

the sgRNAs were designed targeting Dgcr2 intron9 and Hira intron24 resulting in a sequence deletion of approximately 0.11 mb between the Dgcr2 gene and the Hira gene.

Mice

Gpr89/Prkab2-KO

Strain Name：C57BL/6Smoc-Gpr89em1Prkab2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18055

The sgRNAs were designed targeting Gpr89 intron11 and Prkab2 intron7 resulting in a sequence deletion of approximately 790 Kb between the Gpr89 gene and the Prkab2 gene.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

Pdyn-IRES-Cre

Strain Name：C57BL/6Smoc-Pdynem1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200089

A IRES-iCre expression cassette was knocked into the Pdyn gene stop codon site. Pdyn encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying depression, stress, anxiety, pain response, circadian rhythm and appetite control.

Mice

Npy5r-KO

Strain Name：C57BL/6Smoc-Npy5Rem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-190602

Exon 2 of Npy5r gene was deleted to generate Npy5r knockout mice.

Rats

App-KO(SD)

Strain Name：SD-Appem1Smoc Strain State：Repository Live | Cat. NO.：NR-KO-210155

Exon3 of App gene was deleted to generate App knockout rats.

Rats

hAPP(SD)

Strain Name：SD-Appem1(hAPP)Smoc Strain State：Developing | Cat. NO.：NR-HU-225062

The endogenous rat App gene was replaced by human APP gene.

Rats

hAPP mutation(SD)

Strain Name：SD-Apptm1(hAPP mutation)Smoc Strain State：Repository Live | Cat. NO.：NR-HU-225063

The endogenous rat App gene was replaced by human APP mutation gene.

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