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Models

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Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001
Validation Data：Presence

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Itgb2-KO

Strain Name：C57BL/6Smoc-Itgb2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190828

Exon 4 of Itgb2 gene was deleted to generate Itgb2 knockout mice.

Mice

Cyp11b1-KO

Strain Name：C57BL/6Smoc-Cyp11b1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200942

Exon 2-3 of Cyp11b1 gene was deleted to generate Cyp11b1 knockout mice.

Mice

Star-KO

Strain Name：C57BL/6Smoc-Starem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201346

Exon 2-3 of Star gene was deleted to generate Star knockout mice.

Mice

Fermt3-KO

Strain Name：C57BL/6Smoc-Fermt3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-210287

Exon 3-6 of Fermt3 gene was deleted to generate Fermt3 knockout mice

Mice

Rasgrp2-KO

Strain Name：C57BL/6Smoc-Rasgrp2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-201049

Exon 3 of Rasgrp2 gene was deleted to generate Rasgrp2 knockout mice.

Mice

Mdk-KO

Strain Name：C57BL/6Smoc-Mdkem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200359

Exon 3-4 of Mdk gene was deleted to generate Mdk knockout mice.

Mice

Lgals3-KO

Strain Name：C57BL/6Smoc-Lgals3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190107

This Lgals3 knockout mouse model was generated by knocking out the exon 3-4 region of the Lgals3 .

Mice

Cdh17-KO

Strain Name：C57BL/6Smoc-Cdh17em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200109

Exon 5 of Cdh17 gene was deleted to generate Cdh17 knockout mice.

Mice

Bpifa1-Flox

Strain Name：B6;129S-Bpifa1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00074

These mice carry loxP sites flanking exon 3. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

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