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Models

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Mice

Ifngr1/Ifnar1-KO

Strain Name：C57BL/6Smoc-Ifngr1em1Ifnar1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190425

This Ifngr1 and Ifnar1 double knockout strain is established by crossing Ifngr1-KO and Ifnar1-KO mice together.

Mice

Cd200-KO

Strain Name：C57BL/6Smoc-Cd200em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190029

This Cd200 knockout mouse model was generated by knocking out the exon 2 region of the Cd200 .

Mice

hFCGR2B/h4-1BB(2)

Strain Name：C57BL/6Smoc-Fcgr2bem2(FCGR2B)Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210352

hFCGR2B(NM-HU-2000010) was crossed with h4-1BB (NM-HU-190077) to generate hFCGR2B/h4-1BB mice.

Mice

hSIRPA(BALB/c,2)

Strain Name：BALB/cAnSmoc-Sirpatm(hSIRPA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210369

The endogenous mice Sirpa gene was replaced by human SIRPA gene.While hSIRPA(BALB/c)(Stock No.NM-HU-2000041) mice function similarly to hSIRPA(BALB/c,2) mice, for more detailed information please contact our technical advisor.

Mice

hFCGRT(NMG）

Strain Name：NOD-PrkdcscidIl2rgem1Fcgrtem2(FCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-020

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.

Mice

Il12a-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il12aem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00024

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il12a.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icoslem1(hICOSLG) Icosem1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

hCSF2RB

Strain Name：C57BL/6Smoc-Csf2rbtm1(hCSF2RB)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225078

The endogenous mouse Csf2rb gene was replaced by human CSF2RB gene.

Mice

hTP53(2)

Strain Name：C57BL/6Smoc-Trp53tm1(hTP53)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225052

The endogenous mouse Trp53 gene was replaced by human TP53 gene.

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