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Models

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Mice

hCEACAM5-Tg

Strain Name：C57BL/6Smoc-Tg(hCEACAM5)1Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-225005

These transgenic mice harbor hCEACAM5 expression cassettes.

Mice

hCSF1/hCSF1R(BALB/c)

Strain Name：BALB/cAnSmoc-Csf1tm2(CSF1)Csf1rem3(hCSF1R)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220016

The endogenous mouse Csf1 and Csf1r genes was replaced respectively by human CSF1 and CSF1R genes.

Mice

hOX40(2)

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00078

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

Mice

Cd2-2A-CreERT2

Strain Name：C57BL/6Smoc-Cd2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18017

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Cd2 gene via homologous recombination to establish a tamoxifen inducible Cd2-CreERT2 tool stain. This strain can be used to knockout target gene in T cells and B cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6raem1(hIL6R)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hVEGFR2

Strain Name：C57BL/6Smoc-Kdrtm2(hKDR) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00098

The endogenous mouse Kdr gene was replaced by human KDR gene .

Mice

hTNFR2/hPD-1

Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210407

hTNFRSF1B(NM-HU-190010) was crossed with hPD-1（NM-HU-00015）to generate hTNFRSF1B/hPD-1 mice

Mice

Ctsk-2A-Cre

Strain Name：C57BL/6Smoc-Ctskem1(2A-Cre-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190019

The 2A-Cre-Wpre-polyA cassette is inserted before 3'UTR region of Ctsk gene.

Mice

Akt2-KO

Strain Name：C57BL/6Smoc-Akt2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190742

Exon 3-4 of Akt2 gene was deleted to generate Akt2 knockout mice.

Mice

hTIGIT/hTNFR2

Strain Name：C57BL/6Smoc-Tigittm3(hTIGIT)Tnfrsf1bem2(hTNFRSF1B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210371

hTIGIT(3)(NM-HU-200244) was crossed with hTNFRSF1B(NM-HU-190010）to generate hTIGIT(3)/hTNFRSF1B mice

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