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Models

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Mice

hCSF1/hCSF1R(2)

Strain Name：C57BL/6Smoc-Csf1tm2(CSF1)Csf1rtm3(hCSF1R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200273

hCSF1(NM-HU-190043) was crossed with hCSF1R(NM-HU-190074)to generate hCSF1/hCSF1R(2) mice.

Mice

Avil-Cre

Strain Name：C57BL/6Smoc-Avilem1(Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-215036
Validation Data：Presence

Cre expression cassette was knocked into the Avil gene.

Mice

hCD160

Strain Name：C57BL/6Smoc-Cd160tm1(CD160)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190057

The endogenous mouse Cd160 gene was replaced by human CD160 gene.

Mice

hPD-1/hCTLA-4

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00079
Validation Data：Presence

hPD-1(NM-HU-00015) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

hVSIG4

Strain Name：C57BL/6Smoc-Vsig4tm1(hVSIG4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210004
Validation Data：Presence

The endogenous mice Vsig4 gene was replaced by human VSIG4 gene

Mice

hCCR8/hPD-1

Strain Name：C57BL/6Smoc-Ccr8tm1(hCCR8)Pdcd1tm1(hPDCD1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210400

hCCR8(NM-HU-190053) was crossed with hPD-1(NM-HU-00015) to generate hCCR8/hPD-1 mice.

Mice

hVEGFA(2)

Strain Name：C57BL/6Smoc-Vegfatm1(hVEGFA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204984
Validation Data：Presence

The endogenous mice Vegfa gene was replaced by human VEGFA gene. While hVEGFA(Stock No.NM-HU-2000028) mice function similarly to hVEGFA(2) mice,for more detailed information please contact our technical advisor.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Slco1c1-2A-CreERT2

Strain Name：C57BL/6Smoc-Slco1c1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200262
Validation Data：Presence

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.

Mice

hCCR8/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8tm1(hCCR8)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210435

hCCR8(NM-HU-190053) was crossed with hCTLA4(NM-HU-00014) to generate hCCR8/hCTLA4 mice.

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