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Models

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Mice

hB7H3/hPD-1

Strain Name：C57BL/6Smoc-Cd276tm2(hCD276)Pdcd1tm1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210349

hB7-H3(NM-HU-00107) was crossed with hPD-1(NM-HU-00015) to generate hB7H3/hPD-1 mice.

Mice

hALB

Strain Name：C57BL/6Smoc-Albtm3(ALB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200003
Validation Data：Presence

The endogenous mouse Alb gene was replaced by human ALB gene.

Mice

hTLR8

Strain Name：C57BL/6Smoc-Tlr8tm2(TLR8)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190044
Validation Data：Presence

The endogenous mouse Tlr8 gene was replaced by human TLR8 gene.

Mice

Tagln-Cre

Strain Name：C57BL/6Smoc-Taglnem1(Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200144
Validation Data：Presence

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.

Mice

hBTLA(2)

Strain Name：C57BL/6Smoc-Btlatm2(hBTLA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190040
Validation Data：Presence

Extracellular domain of mouse Btla gene was replaced by human BTLA gene. While hBTLA mice(Stock No.NM-HU-18014）have been pulled from shelves for some reasons.

Mice

hCD20(2)

Strain Name：C57BL/6Smoc-Ms4a1tm3(hCD20)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200114
Validation Data：Presence

Extracellular and transmembrane region of the endogenous mouse Ms4a1 gene was replaced by corresponding region of human CD20 gene. While hCD20(Stock No.NM-HU-190068) mice function similarly to hCD20(2) mice,for more detailed information please contact our technical advisor.

Mice

hCD3E

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00114
Validation Data：Presence

The endogenous mouse Cd3e gene was replaced by human CD3E gene . While hCD3E(2)(Stock No.NM-HU-210023) mice function similarly to hCD3E mice,for more detailed information please contact our technical advisor.

Mice

hCRBN

Strain Name：C57BL/6Smoc-Crbntm1(hCRBN)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225071
Validation Data：Presence

The endogenous mouse Crbn gene was replaced by human CRBN gene.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Scgb3a2-IRES-Cre

Strain Name：C57BL/6Smoc-Scgb3a2em1(IRES-Cre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210127
Validation Data：Presence

IRES-Cre-polyA expression cassette was knocked into the Scgb3a2 gene.

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