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Models

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Mice

hTLR9

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-18016

This TLR9 humanized mouse model was established by replacing the mouse Tlr9 gene exon2 with the human TLR9 corresponding sequence by homologous recombination.

Mice

Scgb3a2-IRES-Cre

Strain Name：C57BL/6Smoc-Scgb3a2em1(IRES-Cre-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210127

IRES-Cre-polyA expression cassette was knocked into the Scgb3a2 gene.

Mice

H11-CAG-RSR-EYFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-RSR-EYFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18056

A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.

Mice

Pdcd1-DTR-2A-tdTomato

Strain Name：C57BL/6Smoc-Pdcd1em1(DTR-2A-tdTomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200225

A DTR-2A-tdTomato-WPRE-pA expression cassette was knocked into the Pdcd1 gene start codon site.

Mice

hCALCRL

Strain Name：C57BL/6Smoc-Calcrlem1(hCALCRL)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225031

The endogenous mouse Calcrl gene was replaced by human CALCRL gene.

Mice

hCB1

Strain Name：C57BL/6Smoc-Cnr1em1(hCB1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225027

The endogenous mouse Cnr1 gene was replaced by human CB1 gene.

Mice

Il1b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00010

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Mice

hB2M-HLA A2.1(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1H2-D1em1(hB2M-HLA A2.1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-225089

The endogenous mouse H2-D1 gene was replaced by human B2M-HLA A2.1 gene.

Mice

hTNFR2

Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190010

The endogenous mouse Tnfrsf1b gene was replaced by human TNFRSF1B gene.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

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