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Models

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Mice

hFAS

Strain Name：C57BL/6Smoc-Fastm1(hTNFRSF6)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210007
Validation Data：Presence

The endogenous mice Fas gene was replaced by human FAS gene.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018
Validation Data：Presence

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD3E/hPD-L1

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd274tm1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210449
Validation Data：Presence

hCD3E(NM-HU-00114) was crossed with hPD-L1(NM-HU-00062) to generate hCD3E/hPD-L1 mice

Mice

hHER3(2)

Strain Name：C57BL/6Smoc-Erbb3tm2(hERBB3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225068
Validation Data：Presence

The endogenous mouse Erbb3 gene was replaced by human ERBB3 gene.

Mice

hPD-L2(BALB/c)

Strain Name：BALB/cAnSmoc-Pdcd1lg2tm1(hPDCD1LG2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190061

The endogenous mouse Pdcd1lg2 gene was replaced by human PDCD1LG2 gene.

Mice

Ahi1-Flox

Strain Name：B6;129S-Ahi1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00053

These mice possess loxP sites on either side of exon 3 the Ahi1 (Abelson helper integration site 1) gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

hIL21R

Strain Name：C57BL/6Smoc-Il21rtm1(hIL21R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210031
Validation Data：Presence

The endogenous mice Il21r gene was completely or partially replaced by human IL21R gene via ESC targeting.

Mice

Col2a1-2A-CreERT2

Strain Name：C57BL/6Smoc-Col2a1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18029
Validation Data：Presence  |  Publications：1piece

A 2A-CreERT2 expression cassette was knocked into the stop codon of Col2a1 gene to establish a Col2a1-CreERT2 recombinase tool mouse.The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

hRSPO1

Strain Name：C57BL/6Smoc-Rspo1tm1(hRSPO1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225041
Validation Data：Presence

The endogenous mouse Rspo1 gene was replaced by human RSPO1 gene.

Mice

hLILRB4

Strain Name：C57BL/6Smoc-Lilrb4atm1(hLILRB4 )Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210024
Validation Data：Presence

The endogenous mice Lilrb4a gene was completely or partially replaced by human LILRB4 gene via CRISPR/Cas9 mediated recombination.

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