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Genotyping method for CRISPR/Cas9 Knockout mouse

Genotyping method for CRISPR/Cas9 point mutation mouse

Endocrinology and Metabolism

Diabetic mouse model type 2 diabetes mouse model

Long-term feeding of high-fat diets can cause obesity and increased fasting blood glucose in mice along with fat accumulation and insulin resistance in the body to mimic human type II diabetes.

Excision and Regeneration of Tissue

liver regeneration subtotal gastrectomy

A mouse tissue regeneration model can be established by an operation of partial tissue excision. Such models can be used to study the changes in morphology, serology and metabolism during tissue regeneration, and hence lay the experimental foundation for studying the mechanisms regulating tissue regeneration.

Surgical & Preconditioning Services

Why IL-2 Still Holds Promise in Therapeutics of Cancer and Autoimmunity

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Study of Gene Functions

gene functions methods to study gene function what are the functions of genes

Dysgenesis model

infertility diseases prss37 gene KO mice

Prss37 gene knockout infertility mouse model. SMOC has developed the Prss37 gene knockout mouse model (Prss37 KO, Model No.: NM -KO-00016) by ES cell targeting. It is a homozygous male infertility model.

Humanized Mice

NMG mice with human-derived CD34+ hematopoietic stem cells can be used for reconstruction of multi-lineage human immune cells, and represent effective model animals for studies on immuno-oncology and infectious diseases.