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Sept5-KO(2)

Strain Name：C57BL/6Smoc-Sept5^emSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210168

Sept5-KO(2) mice (Stock No.NM-KO-210168) carry a knockout allele derived from the targeted deletion of exon 3-8. While Ptgs2-KO mice(Stock No.NM-KO-191030）carrying the exon 2 deletion.

Hif3a-KO(2)

Strain Name：C57BL/6Smoc-Hif3a^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-210081

Hif3a-KO(2) mice(Stock No.NM-KO-210081) carry a knockout allele derived from the targeted deletion of exon 7-8. While Hif3a-KO mice(Stock No.NM-KO-191062) carrying the exon 3 deletion.

Foxn1-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Foxn1^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200735

Foxn1-KO(BALB/c) mice (Stock No.NM-KO-200735）carry a knockout allele derived from the targeted deletion of exon 5. While Foxn1-KO(BALB/c,2) mice (Stock No.NM-KO-205001）mice carrying the exon 2-9 deletion.

Thy1-KO(2)

Strain Name：C57BL/6Smoc-Thy1^em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200714

Thy1-KO(2) mice(Stock No.NM-KO-NM-KO-200714）carry a knockout allele derived from the targeted deletion of exon 3-4. While Thy1-KO mice (Stock No.NM-KO-190162) carrying the exon 2-4 deletion.

Foxn1-KO(BALB/c,2)

Strain Name：BALB/cAnSmoc-Foxn1^em3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-205001

Foxn1-KO(BALB/c,2) mice (Stock No.NM-KO-205001）carry a knockout allele derived from the targeted deletion of exon 2-9. While Foxn1-KO(BALB/c) mice (Stock No.NM-KO-200735）mice carrying the exon 5 deletion.

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2^{em1(CAG-LSL-Myc)Smoc}
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

F9-KO

Strain Name：C57BL/6Smoc-F9^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18046
Validation Data：Presence  |  Publications：1piece

The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046）carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion.

Acan-IRES-CreERT2

Strain Name：C57BL/6Smoc-Acan^{em1(IRES-CreERT2)Smoc}
Strain State：Repository Live | Cat. NO.：NM-KI-200143
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Acan gene stop codon site via CRISPR/Cas9 mediated recombination.

Nkx2-5-IRES-Cre

Strain Name：C57BL/6Smoc-Nkx2-5^{em1(IRES-Cre-WPRE-polyA)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200152
Validation Data：Presence

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Nkx2-5 gene stop codon site.

FYB1-targeted modulation of CAPG promotes AML progression

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