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Models

About 79 results
Mice

Plp1-Flox

Strain Name：C57BL/6Smoc-Plp1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200072

These mice carry loxP sites flanking exon 3 of Plp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Plp1 gene.

Mice

Slc32a1-Flox

Strain Name：C57BL/6Smoc-Slc32a1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200219

These mice carry loxP sites flanking exon 2 of Slc32a1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Slc32a1 gene.

Mice

Ptgs2-Flox

Strain Name：C57BL/6Smoc-Ptgs2em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200129

These mice carry loxP sites flanking exon 4-5 of Ptgs2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ptgs2 gene.

Mice

Eno2-2A-Cre

Strain Name：C57BL/6Smoc-Eno2em1(2A-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200012

A 2A-iCre expression cassette was knocked into the Eno2 gene stop codon site.

Mice

Il1b-Luc-Tg

Strain Name：B6.Cg-Tg(IL1B-luc)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00001

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

Mice

Sftpc-IRES-CreERT2

Strain Name：C57BL/6Smoc-Sftpcem(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18020

An IRES-CreERT2 co-expression cassette is inserted into 3'UTR region of Sftpc gene via homologous recombination to establish a tamoxifen inducible Sftpc-CreERT2 tool stain. *This strain CreERT2 has leakage (see validation data for details), please select according to the purpose of the study。

Mice

Stat1-Flox

Strain Name：C57BL/6Smoc-Stat1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200139

These mice carry loxP sites flanking exon 2-5 of Stat1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat1 gene.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

R26-CAG-LSL-mCherry-EGFP-LC3

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-mCherry-EGFP-Map1lc3a-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00124

The CAG promoter-loxp-stop-loxp-mCherry-EGFP-Map1lc3a-WPRE-polyA expression cassette was inserted into the Rosa26 gene locus by homologous recombination. Map1lc3a, also known as LC3, is a widely expressed autophagic vesicle-specific marker. There was no abnormality in heterozygous mice. The presence of the loxp-stop-loxp expression cassette prevented the transcription of the downstream target gene LC3. After mating with Cre mice, LC3 gene is driven by the CAG promoter to express mCherry and EGFP in a pH-dependent manner in phagocytic cells after ischemic injury in the progeny double positive mice. The two co-expressed fluorescent signals vary depending on the acidic environment of the autophagic vesicles within the cell. mCherry is stable in an acidic environment (pKa 4.5), and quenching occurs in the acidic environment (pKa 5.9) of EGFP in lysosomes. In the autophagy vesicles with higher pH, the fluorescence of GFP and mCherry superimposed on yellow fluorescence; while in the lower pH lysosome, EGFP was quenched and only red fluorescence signal was detected. It can be used to label and track LC3 and study the origin, progression and disappearance of autophagy in various tissues after ischemic injury.

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