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Mice

Col2a1-2A-CreERT2

Strain Name：C57BL/6Smoc-Col2a1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18029
Validation Data：Presence  |  Publications：1piece

A 2A-CreERT2 expression cassette was knocked into the stop codon of Col2a1 gene to establish a Col2a1-CreERT2 recombinase tool mouse.The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

Col1a1-IRES-EGFP-IRES-MerCreMer

Strain Name：C57BL/6Smoc-Col1a1em1(IRES-EGFP-IRES-MerCreMer)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-240492
Validation Data：Presence

The IRES-EGFP-IRES-MerCreMer expression cassette was knocked into the Col1a1 gene stop codon site. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

Col1a1-tetO-EML4-ALK

Strain Name：C57BL/6Smoc-Col1a1tm1(TetO-EML4-ALK)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：DM-KI-251860

The human EML4-ALK gene was cloned into a TetO-EML4-ALK construct and microinjected into FVB zygotes, where it was inserted into the mouse Col1a1 locus. This strain was donated by the laboratory of Academician Liang Chen at Jinan University. Any published research papers or other forms of literature should cite: "Zhou Q, Yang T, Yu X, et al. Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity. EMBO Mol Med. 2025;17(3):563-588. doi:10.1038/s44321-025-00200-y"

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

R26-CAG-LSL-mTurquoise2-SLBP(18-126)-2A-H1-mMaroon1

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-mTurquoise2-SLBP(18-126)-P2A-H1-mMaroon1-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200007

These mice harbor a SA-Frt-2xpolyA-CAG-Frt-LSL-mTurquoise2-SLBP(18-126)-P2A-H1-mMaroon1-WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-CAG-LSL-Clover-Geminin(1-110)-2A-mKO2-Cdt(30-120)

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-Clover-Geminin(1-110)-P2A-mKO2-Cdt(30-120)-WPRE-PA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200008

These mice harbor a SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-Clover-Geminin(1-110)-P2A-mKO2-Cdt(30-120)-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

hTLR8/Lyz2-DTREGFP

Strain Name：C57BL/6Smoc-Lyz2tm3(IRES-DTREGFP)Tlr8tm2(TLR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200259

NM-KI-190041 was crossed with NM-HU-190044 to generate hTLR8/Lyz2-IRES-DTREGFP mice.

Mice

hHBB

Strain Name：C57BL/6Smoc-Hbb-bt&Hbb-bstm1(hHBB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000080
Validation Data：Presence

The endogenous mouse Hbb-bt and Hbb-bs gene was replaced by human HBB gene.

Mice

hGLP1R

Strain Name：C57BL/6Smoc-Glp1rtm2(hGLP1R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200220
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Glp1r gene was completely or partially replaced by human hGLP1R gene via CRISPR/Cas9 mediated recombination.

Mice

hPD-L1/hCD28

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Cd28tm2(hCD28)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210019

hPD-L1(NM-HU-00062) was crossed with hCD28(NM-HU-190011) to generate hPD-L1/hCD28 mice

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