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Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

R26-CAG-LSL-hWNT1

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-WNT1-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190128

These mice harbor a SA-Frt-2xpA-CAG-Frt-LSL-WNT1-IRES-Luc-2A-tdTomato-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200106

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

Pfkp-KO

Strain Name：C57BL/6Smoc-Pfkpem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190555

Pde4d-KO mice (Stock No.NM-KO-190555） carry a knockout allele derived from the targeted deletion of exon 4.

Mice

Dicer1-Flox

Strain Name：C57BL/6Smoc-Dicer1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200158

These mice carry loxP sites flanking exon 23 of Dicer1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dicer1 gene.

Mice

Hif1a-Flox

Strain Name：C57BL/6Smoc-Hif1atm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190065

These mice carry loxP sites flanking exon 2 of Hif1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hif1a gene.

Mice

Wnt11-Flox

Strain Name：C57BL/6Smoc-Wnt11em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200146

These mice carry loxP sites flanking exon 4 of Wnt11 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Wnt11 gene.

Mice

Wrn-KO

Strain Name：C57BL/6Smoc-Wrnem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190902

Exon 5-8 of Wrn gene was deleted to generate Wrn knockout mice.

Mice

Ptf1a-CreERT2

Strain Name：C57BL/6Smoc-Ptf1aem1(CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200118

A CreERT2-WPRE-pA expression cassette was knocked into the Ptf1a gene start codon site.

Mice

Adrb3-KO

Strain Name：C57BL/6Smoc-Adrb3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190739

Exon 2 of Adrb3 gene was deleted to generate Adrb3 knockout mice.

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