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Models

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Mice

hPD-1/hCD28

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd28em2(hCD28)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000097

hPD-1(NM-HU-00015) was crossed with hCD28(NM-HU-190011) to generate hPD-1/hCD28.

Mice

hLAIR1

Strain Name：C57BL/6Smoc-Lair1em2(LAIR1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000011

The endogenous mouse Lair1 gene was replaced by human LAIR1 gene .

Mice

hIL17RA

Strain Name：C57BL/6Smoc-Il17ratm1(hIL17RA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190049

The endogenous mouse Il17ra gene was replaced by human IL17RA gene.

Mice

hIL4

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190071

The endogenous mouse Il4 gene was completely or partially replaced by human IL4 gene via ESC targeting.

Mice

hPD-1/hCD27(2)

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd27tm2(hCD27)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000096

hPD-1(NM-HU-00015) was crossed with hCD27(2)(NM-HU-190035) to generate hPD-1/hCD27(2).

Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

Becn1-KO

Strain Name：C57BL/6Smoc-Becn1em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18028

Exon3 of Becn1 gene were deleted to generate Becn1 knockout mice.

Mice

Ambra1-Flox

Strain Name：C57BL/6Smoc-Ambra1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200059

These mice carry loxP sites flanking exon4 of Ambra1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ambra1 gene.

Mice

Taz-Flox

Strain Name：C57BL/6Smoc-Tazem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200001

These mice carry loxP sites flanking exon5-10 of Taz gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Taz gene.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

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