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Models

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Mice

ICR

Strain Name：Smoc:ICR
Strain State：Repository Live | Cat. NO.：SM-006

ICR mice have good reproductive performance, strong disease resistance, a gentle temperament, and are generally used for safety evaluation, pharmacological and toxicological research, aging research, surgical experiments, and so on. They are also suitable for surrogate suckling and false pregnancy.

Mice

H11-pThy1-hPSEN1-IRES-tdTomato

Strain Name：C57BL/6Smoc-Igs2em1(pThy1-PSEN1-IRES-tdTomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18049

A Thy1 promoter-PSEN1-IRES-tdTomato-WPRE-polyA cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) .

Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

hB7H3

Strain Name：C57BL/6Smoc-Cd276tm2(hB7H3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00107

The endogenous mouse Cd276 gene was replaced by human CD276 gene.

Mice

Btg2-KO

Strain Name：C57BL/6Smoc-Btg2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200587

Exon 2 of Btg2 gene was deleted to generate Btg2 knockout mice.

Mice

Reg3b-KO

Strain Name：C57BL/6Smoc-Reg3bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200709

Reg3b-KO mice (Stock No.NM-KO-200709） carry a knockout allele derived from the targeted deletion of exon 3-4. While Reg3b-KO(2) mice (Stock No.NM-KO-200791）carrying the exon 2-6 deletion.

Mice

Tgfb2-KO

Strain Name：C57BL/6Smoc-Tgfb2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190548

Exon 4 of Tgfb2 gene was deleted to generate Tgfb2 knockout mice.

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