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Models

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Mice

B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

R26-CAG-LSL-hBCR/ABL

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-loxp-STOP-loxp-BCR-ABL-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190127

These mice harbor a CAG-LSL-BCR-ABL-IRES-Luciferase-2A-tdTomato-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

Wrn-KO

Strain Name：C57BL/6Smoc-Wrnem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190902

Exon 5-8 of Wrn gene was deleted to generate Wrn knockout mice.

Mice

Cth-Luc

Strain Name：B6;129S-Cthtm1(Luc)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00004

Cth was targeted by insertion of a floxed Luciferase gene and an frt-neo-frt cassette before exon 1. These mice have normal development and fertility.

Mice

Il13/Il4-Flox

Strain Name：C57BL/6Smoc-Il13tm1(flox)Il4tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200169

These mice carry loxP sites flanking region between exon 3 of Il13--201 and exon 4 of Il4-201 . When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il13 and IL4 gene.

Mice

Vpreb1-KO

Strain Name：C57BL/6Smoc-Vpreb1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200688

Exon 1-2 of Vpreb1 gene was deleted to generate Vpreb1 knockout mice.

Mice

Nae1-KO

Strain Name：C57BL/6Smoc-Nae1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190842

Exon 2 of Nae1 gene was deleted to generate Nae1 knockout mice.

Mice

Fto-Flox

Strain Name：C57BL/6Smoc-Ftoem3(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-190005

These mice carry loxP sites flanking exon3 of Fto gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Fto gene.

Mice

R26-CAG-LSL-hTARDBP*A315T-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-3xFlag-TARDBP(A315T)-IRES-GFP-WPRE-PA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200019

These mice harbor a CAG-LSL-3xFlag-TARDBP(A315T)-IRES-GFP-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

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