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Models

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Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001
Validation Data：Presence

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Il10-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Il10em4Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200637

Exon 1-5 of Il10 gene was deleted to generate Il10 knockout mice.

Mice

Tsc1-Flox

Strain Name：C57BL/6Smoc-Tsc1tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200231

These mice carry loxP sites flanking exon 17-18 of Tsc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tsc1 gene.

Mice

Bmp1-Flox

Strain Name：C57BL/6Smoc-Bmp1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200065

These mice carry loxP sites flanking exon 3-6 of Bmp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmp1 gene.

Mice

Sox10-KO

Strain Name：C57BL/6Smoc-Sox10em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200645

Exon 4-5 of Sox10 gene was deleted to generate Sox10 knockout mice.

Mice

Dmp1-KO

Strain Name：C57BL/6Smoc-Dmp1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200634

Exon 4-6 of Dmp1 gene was deleted to generate Dmp1 knockout mice.

Mice

Slc34a1-KO

Strain Name：C57BL/6Smoc-Slc34a1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200642

Exon 3-6 of Slc34a1 gene was deleted to generate Slc34a1 knockout mice.

Mice

Smarcad1-KO

Strain Name：C57BL/6Smoc-Smarcad1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200643

Exon 3 of Smarcad1 gene was deleted to generate Smarcad1 knockout mice.

Mice

Acly-Flox

Strain Name：C57BL/6Smoc-Aclyem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200076

These mice carry loxP sites flanking exon 9 of Acly gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Acly gene.

Mice

Lmx1b-Flox

Strain Name：C57BL/6Smoc-Lmx1bem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200117

These mice carry loxP sites flanking exon 4-6 of Lmx1b gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Lmx1b gene.

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