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Models

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Mice

Adrb3-KO

Strain Name：C57BL/6Smoc-Adrb3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190739

Exon 2 of Adrb3 gene was deleted to generate Adrb3 knockout mice.

Mice

Agt-KO

Strain Name：C57BL/6Smoc-Agtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190740

Exon 2-5 of Agt gene was deleted to generate Agt knockout mice.

Mice

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

Mice

Col2a1-2A-CreERT2

Strain Name：C57BL/6Smoc-Col2a1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18029

A 2A-CreERT2 expression cassette was knocked into the stop codon of Col2a1 gene to establish a Col2a1-CreERT2 recombinase tool mouse.The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

ICR

Strain Name：Smoc:ICR
Strain State：Repository Live | Cat. NO.：SM-006

ICR mice have good reproductive performance, strong disease resistance, a gentle temperament, and are generally used for safety evaluation, pharmacological and toxicological research, aging research, surgical experiments, and so on. They are also suitable for surrogate suckling and false pregnancy.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Il10-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Il10em4Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200637

Exon 1-5 of Il10 gene was deleted to generate Il10 knockout mice.

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