Welcome to Advanced Search

Models

About 546 results
Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

Gpr65-IRES-Cre

Strain Name：C57BL/6Smoc-Gpr65em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200135

A IRES-iCre expression cassette was knocked into the Gpr65 gene stop codon site.

Mice

Stag2-Flox

Strain Name：C57BL/6Smoc-Stag2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200138

These mice carry loxP sites flanking exon 7 of Stag2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stag2 gene.

Mice

Ptk2-Flox

Strain Name：C57BL/6Smoc-Ptk2em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200130

These mice carry loxP sites flanking exon 4 of Ptk2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ptk2 gene.

Mice

Emp2-Flox

Strain Name：C57BL/6Smoc-Emp2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200074

These mice carry loxP sites flanking exon 3 of Emp2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Emp2 gene.

Mice

Esr1-Flox(2)

Strain Name：C57BL/6Smoc-Esr1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200175

These mice carry loxP sites flanking exon 3 of Esr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Esr1 gene.While Esr1-Flox(Stock No.NM-CKO-200024）mice carrying the loxP sites flanking exon 4 of Esr1 gene.

Mice

Gata3-Flox

Strain Name：C57BL/6Smoc-Gata3em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200096

These mice carry loxP sites flanking exon 4 of Gata3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gata3 gene.

Mice

Birc5-Flox

Strain Name：C57BL/6Smoc-Birc5em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200082

These mice carry loxP sites flanking exon 2 of Birc5 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Birc5 gene.

Mice

Traf6-Flox

Strain Name：C57BL/6Smoc-Traf6em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200144

These mice carry loxP sites flanking exon 8 of Traf6 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Traf6 gene.

Mice

Smc3-Flox

Strain Name：C57BL/6Smoc-Smc3em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200135

These mice carry loxP sites flanking exon 4 of Smc3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Smc3 gene.

Email Back to top