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Models

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Mice

Trp53-R270H

Strain Name：C57BL/6Smoc-Trp53em3(R270H)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18027

These mice carry a p.R270H mutation of Trp53 gene.

Mice

Trp53-Frox

Strain Name：C57BL/6Smoc-Trp53em1(rox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-190067

These mice carry rox sites flanking exon 5-7 of Trp53 gene. When crossed with a Dre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Trp53 gene.

Mice

Trp53-R245W

Strain Name：C57BL/6Smoc-Trp53em(R245W)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225098

These mice carry a R245W mutation of Trp53 gene.

Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

KPC(2)

Strain Name：C57BL/6Smoc-Trp53tm7(R270H-flox)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-220014

Trp53-LSL-R270H, Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. While KPC mice function similarly to KPC(2) mice, for more detailed information please contact our technical advisor.

Mice

Wap-Trp53*R172H-Tg

Strain Name：C57BL/6Smoc-Tg(Wap-P53(R172H))1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-TG-220193

These transgenic mice harbor Wap-P53(R172H) expression cassettes.

Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

hTP53(2)

Strain Name：C57BL/6Smoc-Trp53tm1(hTP53)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225052

The endogenous mouse Trp53 gene was replaced by human TP53 gene.

Rats

Tp53-KO(SD)

Strain Name：SD-Tp53em1Smoc Strain State：Repository Live | Cat. NO.：NR-KO-210134

Exon3-4 of Tp53 gene was deleted to generate Tp53 knockout rats.

Literature

NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

Model Organisms：细胞 Product & Service：N/A Research field：N/A

细胞

Published date：2016-02-01 | References：EMBO Rep

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