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Plekhm1-Flox

Strain Name：C57BL/6Smoc-Plekhm1^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Plekhm1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Plekhm1 gene.

Ifngr1-KO(2)

Strain Name：C57BL/6Smoc-Ifngr1^em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190432

Ifngr1-KO(2) mice(Stock No.NM-KO-190432) carry a knockout allele derived from the targeted deletion of exon 2. While Ifngr1-KO mice(Stock No.NM-KO-18020) have been pulled from shelves for some reasons.

Opg-KO

Strain Name：B6.129S-Tnfrsf11b^tm1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-00004

Partial exon 2 was replaced with Neo cassette.

Esr1-KO

Strain Name：C57BL/6Smoc-Esr1^em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190631

Esr1-KO mice (Stock No.NM-KO-190631）carry a knockout allele derived from the targeted deletion of exon 3. While Esr1-KO(2) mice (Stock No.NM-KO-200651) carrying the exon 4 deletion.Esr1-KO(3) mice (Stock No.210243) carrying the exon 4 deletion.

Anti-osteoporosis activity of a novel Achyranthes bidentata polysaccharide via stimulating bone formation.

Model Organisms：斑马鱼 Product & Service：- Research field：Skeleton

抗骨质疏松 中药 牛膝 多糖提取物

Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice

Model Organisms：小鼠 Product & Service：APN Research field：Skeleton

骨质疏松 BMD 骨密度

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.

Research on Diseases

genetics diseases studies diseases research diseases

Shanghai Model Organisms provides a professional R&D platform for genetically-engineered mouse, zebrafish and nematode models, a service platform for phenotyping, and a rich repository of disease mouse models to support your studies on disease genetics, pathogenesis, drug treatments, and more.

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