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Models

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Mice

Resp18-KO

Strain Name：B6;129S-Resp18tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00022

These Resp18 knockout mice were established technology and crossed with FLP transgenic mice to delete PGK-Neo gene.

Mice

Alb-CreERT2

Strain Name：B6.129S-Albtm1.1(CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00002

Exons 1-7 were replaced by CreERT2 and a loxp neo casette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.This strain has removed the Neo screening gene.

Mice

Cth-Luc

Strain Name：B6;129S-Cthtm1(Luc)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00004

Cth was targeted by insertion of a floxed Luciferase gene and an frt-neo-frt cassette before exon 1. These mice have normal development and fertility.

Mice

Tet2-KO

Strain Name：B6;129S-Tet2tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00127

Exon3 of mouse Tet2 gene was replaced by frt-Pgk-Neo-polyA-frt cassette by homologous recombination.

Mice

Clec18a-Flox

Strain Name：B6;129S-Clec18atm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00006

These mice possess loxP sites on either side of exon 5 of C-type lectin domain family 18 member A gene and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain,this strain is useful in eliminating tissue-specific con

Mice

Foxd1-Cre-pGK-Neo

Strain Name：C57BL/6Smoc-Foxd1em1(Kozak-Cre-pA-pGK-Neo)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-241417

The Kozak-Cre-pA-pGK-Neo expression cassette was knocked into the Foxd1 gene start codon site.

Mice

Pcp2-Cre-PGK-Neo

Strain Name：C57BL/6Smoc-Pcp2em1(Cre-FRT-PGK-Neo-pA-FRT)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-241053

The Cre-FRT-PGK-Neo-pA-FRT expression cassette was knocked into the Pcp2 gene locus.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Nanog-2A-tdTomato-IRES-Puro

Strain Name：C57BL/6Smoc-Nanogtm2(2A-tdTomato-IRES-Puro-FRT-polyA-PGK-Neo-polyA-FRT)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200246

A 2A-tdTomato-IRES-Puro-FRT-polyA-PGK-Neo-polyA-FRT expression cassette was knocked into the Nanog gene stop codon site.

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