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Models

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Mice

BALB/c Nude

Strain Name:BALB/cAnSmoc-Foxn1nu/Smoc
Strain State:Repository Live | Cat. NO.:SM-014

This strain carries a Foxn1nu mutation on the BALB/c background which will lead to T cell deletion. At the same time, the response to thymus-dependent antigens is limited, resulting in impaired B cell function while NK cells, macrophages, and antigen-presenting cells function normally. The complement activity is normal as well. Hair dysplasia causes aberrant hair growth in which the majority of the hair cannot protrude from the surface, resulting in a naked mouse phenotype.

Mice

R26-CAG-LSL-Zbp1-Mouse-L-3xFLAG-bGH

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Kozak-Zbp1-Mouse-L-3xFLAG-WPRE-bGH-pA)Smoc
Strain State:Developing | Cat. NO.:NM-KI-241596

The CAG-LSL-Kozak-Zbp1-Mouse-L-3xFLAG-WPRE-bGH-pA expression cassette was knocked into the R26 locus.

Mice

R26-CAG-FLEX-Zbp1-Mouse-L-3xFLAG

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-loxP-STOP-lox2272-3xFLAG-Zbp1-Mouse-L-Kozak-loxP-lox2272-WPRE-bGH-pA)Smoc
Strain State:Developing | Cat. NO.:NM-KI-250273

The CAG-loxP-STOP-lox2272-3xFLAG-Zbp1-Mouse-L-Kozak-loxP-lox2272-WPRE-bGH-pA expression cassette was knocked into the R26 locus.

Mice

Ncr1-2A-Cre

Strain Name:C57BL/6Smoc-Ncr1em2(2A-iCre)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190027

A 2A-iCre expression cassette was knocked into the Ncr1 gene stop codon site.

Mice

Ncr1-IRES-mtagBFP2-Luc

Strain Name:C57BL/6Smoc-Ncr1em5(IRES-mtagBFP-luciferase)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-200030

A IRES-mtagBFP-luciferase expression cassette was knocked into the Ncr1 gene stop codon site.

Mice

hPD-1

Strain Name:C57BL/6Smoc-Pdcd1em1(hPDCD1) /Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-00015

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .

Mice

hC3

Strain Name:C57BL/6Smoc-C3em1(hC3)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000079

The endogenous mouse C3 gene was replaced by human C3 gene.

Mice

hPCSK9

Strain Name:C57BL/6Smoc-Pcsk9em2(hPCSK9)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-00075

The endogenous mouse Pcsk9 gene was replaced by human PCSK9 gene .

Mice

hTP53(2)

Strain Name:C57BL/6Smoc-Trp53tm1(hTP53)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-225052

The endogenous mouse Trp53 gene was replaced by human TP53 gene.

Mice

hCD45

Strain Name:C57BL/6Smoc-Ptprctm1(hPTPRC)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-225080

The endogenous mouse Ptprc gene was replaced by human PTPRC gene.

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