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Models

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Mice

HLA-A11.1/B2M(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1B2mtm1(hB2M-linker-HLA-A*1101/H2-D1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-252346
Validation Data：Presence

The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*1101/H2-D1 gene.

Mice

hCRP

Strain Name：C57BL/6Smoc-Crptm1(hCRP)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-242427
Validation Data：Presence

The endogenous mouse Crp gene was replaced by human CRP gene.

Mice

hEGF

Strain Name：C57BL/6Smoc-Egftm1(hEGF)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-241970
Validation Data：Presence

The endogenous mouse Egf gene was replaced by human EGF gene.

Mice

B2m-KO(NMG)

Strain Name：M-NSG-B2memSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-NSG-002
Validation Data：Presence

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

Hc-KO

Strain Name：C57BL/6Smoc-Hcem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190191
Validation Data：Presence

This Hc knockout mouse model was generated by knocking out the exon 6 region of the Hc.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Cdkn2a-KO(p16-KO)

Strain Name：C57BL/6Smoc-Cdkn2aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-240239

Cdkn2a(p16) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p16INK4a transcript (Cdkn2a-201 transcript).

Mice

Flt3-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Flt3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-234079
Validation Data：Presence

The exon3 of Flt3 gene was deleted to generate Flt3 knockout mouse.

Mice

Il1b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00010
Validation Data：Presence  |  Publications：2piece

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Mice

Tmem164-KO

Strain Name：C57BL/6Smoc-Tmem164em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234906

The exon 4 of Tmem164 gene was deleted to generate Tmem164 knockout mouse.

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