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Models

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Mice

Flt3-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Flt3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-234079
Validation Data：Presence

The exon3 of Flt3 gene was deleted to generate Flt3 knockout mouse.

Mice

Il1b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00010
Validation Data：Presence  |  Publications：2piece

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Mice

Tmem164-KO

Strain Name：C57BL/6Smoc-Tmem164em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234906

The exon 4 of Tmem164 gene was deleted to generate Tmem164 knockout mouse.

Mice

Trdc-IRES-CreERT2

Strain Name：C57BL/6Smoc-Trdcem1(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-231464
Validation Data：Presence

The IRES-CreERT2 expression cassette was inserted after the termination codon of the mouse Trdc gene.

Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

R26-CAG-RSR-tdTomato-2A-DTR

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-RSR-tdTomato-2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200191

This mouse was obtained by crossing R26-(CAG-LSL-RSR-tdTomato-2A-DTR) mice with systemic Cre mice.

Mice

hPD-L1

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00062
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene . While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

Mice

hCD81

Strain Name：C57BL/6Smoc-Cd81tm1(CD81)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190041

The endogenous mouse Cd81 gene was replaced by human CD81 gene.

Mice

hDPP4

Strain Name：C57BL/6Smoc-Dpp4tm1(DPP4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190042
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Dpp4 gene was replaced by human DPP4 gene.

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