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Models

About 3,264 results
Mice

Hc-KO

Strain Name：C57BL/6Smoc-Hcem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190191

This Hc knockout mouse model was generated by knocking out the exon 6 region of the Hc.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Cdkn2a-KO(p16-KO)

Strain Name：C57BL/6Smoc-Cdkn2aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-240239

Cdkn2a(p16) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p16INK4a transcript (Cdkn2a-201 transcript).

Mice

Il1b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00010

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Mice

Tmem164-KO

Strain Name：C57BL/6Smoc-Tmem164em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234906

The exon 4 of Tmem164 gene was deleted to generate Tmem164 knockout mouse.

Mice

Trdc-IRES-CreERT2

Strain Name：C57BL/6Smoc-Trdcem1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-231464

The IRES-CreERT2 expression cassette was inserted after the termination codon of the mouse Trdc gene.

Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

hPD-L1

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00062

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene . While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

Mice

hCD81

Strain Name：C57BL/6Smoc-Cd81em1(CD81)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190041

The endogenous mouse Cd81 gene was replaced by human CD81 gene.

Mice

h4-1BB(2)

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190077

The endogenous mouse Tnfrsf9 gene was replaced by human TNFRSF9(4-1BB) gene. While h4-1BB mice(Stock No.NM-HU-00099）have been pulled from shelves for some reasons.

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