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Mice

Rag2/IL2rg-KO/hVEGFR2

Strain Name：C57BL/6Smoc-Il2rgem1Rag2em1Kdrtm2(hKDR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220087

IL2rg-KO (NM-KO-210098) mice were crossed with Rag2-KO/hKDR (NM-HU-200280) mice to generate Rag2/IL2rg-KO/hKDR mouse models.

Mice

Rag2/IL2rg/Flt3-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Flt3em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-234080
Validation Data：Presence

In the background of Rag2/IL2rg-KO (BALB/c)(NM-KO-210231), the exon3 of Flt3 gene was knocked out to establish Rag2, IL2rg and Flt3 gene knockout mouse models.

Mice

MHC Class II (I-A/I-E) -KO

Strain Name：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18032
Validation Data：Presence

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

Tagln-Cre

Strain Name：C57BL/6Smoc-Taglnem1(Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200144
Validation Data：Presence

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.

Mice

FcγR-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgr2bemFcgr3emFcgr4emFcer1gem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-252414

By knocking out exon1-8 of the Fcgr2b gene, exon1-5 of the Fcgr3 gene, and exon1-5 of the Fcgr4 gene, and introducing mutations into exon 1 of the Fcer1g gene, Fcgr2b, Fcgr3, Fcgr4, and Fcer1g gene knockout mouse models were established.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001
Validation Data：Presence  |  Publications：59piece

Prkdc and Il2rg genes were both knocked-out in NOD mice. Lacking mature T, B and NK cells; Low immune rejection against human cells and tissues; Good tumorigenicity so that a small number of cells can form tumors; Significant improvement in the survival of transplanted human cells and tissues; Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models; Suitable as the carrier mice for the transplantation of heterologous cells and tissues.

Mice

NOD SCID

Strain Name：NOD.Cg-Prkdcscid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Rats

Ednrb-KO(SD)

Strain Name：SD-Ednrbem1Smoc Strain State：Developing | Cat. NO.：NR-KO-241785

The exon3-6 of Ednrb gene was knocked out to establish the Ednrb knockout rat model.

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