Welcome to Advanced Search

Models

About 609 results
Mice

B6 DIO

Strain Name：C57BL/6Smoc DIO
Strain State：Repository Live | Cat. NO.：SM-021

Diet-induced obesity (DIO) models are similar to human obesity, can effectively reflect the pathogenesis of human obesity, and are useful for studying metabolic diseases such as obesity, diabetes, and fatty liver disease.

Mice

Tnfrsf1a/Tnfrsf1b-KO

Strain Name：C57BL/6Smoc-Tnfrsf1aem1Tnfrsf1bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18036

This strain is also called p55/p75-KO. The Tnfrsf1a and Tnfrsf1b double knockout mouse models were obtained by knocking out both exon 2-5 region of mouse Tnfrsf1a gene and exon2 of mouse Tnfrsf1b gene. Tnfrsf1a and Tnfrsf1b deletion (p55 and p75 deficiency) homozygous mice are viable and fertile, and these homozygous mice fail to bind TNF (tumor necrosis factor).

Mice

hCD19/hCD3E

Strain Name：C57BL/6Smoc-Cd19tm1(hCD19)Cd3etm1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027
Validation Data：Presence

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4tm3(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6ratm1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018
Validation Data：Presence

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4tm1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Rag2/Il2rg-KO/hSIRPA(BALB/c,2)

Strain Name：BALB/cAnSmoc-Sirpatm(hSIRPA)Rag2em1IL2rgem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234081

On the basis of strain hSIRPA(BALB/c,2), Rag2 and Il2rg gene exon3 and Il2rg gene exon2 were knocked out to establish Rag2 and IL2RG gene knockout mouse models in hSIRPA(BALB/c,2) background.

Email Back to top