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Models

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Mice

Vsir-KO(2)

Strain Name：C57BL/6Smoc-Vsirem5Smoc
Strain State：Developing | Cat. NO.：NM-KO-200649

Vsir-KO(2) mice(Stock No.NM-KO-200649）carry a knockout allele derived from the targeted deletion of exon 2. While Vsir-KO mice (Stock No.NM-KO-18047) carrying the exon 2-3 deletion.

Mice

B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

Hc-KO

Strain Name：C57BL/6Smoc-Hcem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190191

This Hc knockout mouse model was generated by knocking out the exon 6 region of the Hc.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Il1b-Luc-Tg

Strain Name：B6.Cg-Tg(IL1B-luc)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00001

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Mice

Mt1-Flox/Mt2-Flox

Strain Name：C57BL/6Smoc-Mt1 em1（flox）Mt2 em1（flox）Smoc
Strain State：Developing | Cat. NO.：NM-CKO-252576

The MT1-FLOX model was constructed based on Mt2-Flox (NM-CKO-226357) by inserting loxP sites on both sides of exon 2-3 of the Mt1 gene respectively. This flox mouse can be mated with tissue-specific Cre tool mice to obtain mouse models with the Mt1 gene knocked out in specific cell types or tissues.

Mice

hAPOE4

Strain Name：C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

Pd-1-KO

Strain Name：C57BL/6Smoc-Pdcd1em3Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190423

The Pdcd1 knockout mouse model was generated by knocking out the exon2-4 region of the Pdcd1.

Mice

Cptp-KO

Strain Name：C57BL/6Smoc-Cptpem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190061

This Cptp knockout mouse model was generated by knocking out the exon 2-3 region of the Cptp .

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