Therapeutic Target-Humanized Mice
Cre/Dre-Driver Mice
Immunodeficient NMG Mice
Mouse serum mouse serum albumin
At Shanghai Model Organisms Center, we use an automatic biochemical analyzer to measure a specific chemical composition of serum according to the principle of photoelectric colorimetry. This can be used to assess liver and kidney functions or measure blood sugar, blood lipids, and electrolytes.
drug screening high throughput screening for drug discovery
With a comprehensive model organisms service platform that generates the mouse, zebrafish and C. elegans models, Shanghai Model Organisms enables high-throughput drug screening as well as the evaluation and research on drug efficacy, thus accelerating drug development and achieving greater accuracy in the prediction of in vivo interactions.
gene overexpression gene overexpression protocol gene overexpression techniques
Generate a mouse model in which an exogenous gene is introduced and overexpressed. An overexpression model can be used to investigate gene functions, promoter functions, or model the pathogenesis of human disease. Depending on the method to introduce foreign DNA, a random transgenes or targeted conditional overexpression model can be created.
liver regeneration subtotal gastrectomy
A mouse tissue regeneration model can be established by an operation of partial tissue excision. Such models can be used to study the changes in morphology, serology and metabolism during tissue regeneration, and hence lay the experimental foundation for studying the mechanisms regulating tissue regeneration.
Metabolic analysis
There are many mice models used to mimic human metabolic diseases, such as diabetes and obesity, which are caused by nutritional imbalances and metabolic disorders. The detection and analysis of sugar and lipid metabolism phenotypes in these model mice are crucial for the establishment of model mice, the study of disease progression, and the research on the pathogenesis. Shanghai Model Organisms can help your research on metabolism by providing you with a series of testing tools for glucose and lipid metabolisms.
immunotherapy immune checkpoint immune checkpoint genes
As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.
We will delivery the specific genotype model product within specific period by natural breeding or assisted reproduction technology. The specified breeding technologies include natural breeding, assisted reproduction, SPF purification, etc.
As a biotechnology company specializing in animal model R&D, rearing and breeding, as well as analysis and testing, GenoBioTX is dedicated to providing our clients with comprehensive, convenient and professional animal model services.
Our vision is to become the leader in the field of genetically modified animal models，helping people understand the life science and improving quality of life around the world.
上海南方モデル動物バイオテクノロジー株式会社（Shanghai Model Organisms Center, Inc）の薬力学的評価サービスは、二十年の業界経験を積み重ねて、自社開発のU-GEMM®モデルマウスリソースライブラリーを利用して、抗炎免疫、抗腫瘍、心臓血管系、呼吸器系、代謝性疾患など薬物のスクリーニングをする為に、研究者様の求めに応じて 、in vivo 実験、メカニズムの検討、分子生物学研究などの異なるレベルの研究ニーズを満足し、新薬の有効性と安全性を明らかにし、国内外の製薬会社、生物医薬研究機関、新薬開発センター、大学の新薬開発機関などに、専門的な薬力学的評価サービスを提供しております。
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